The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells
Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate carboxylase, thereby inhibiting insulin secretio...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/433046fc179446af96ac4977f8bb7b86 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:433046fc179446af96ac4977f8bb7b86 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:433046fc179446af96ac4977f8bb7b862021-12-02T15:35:46ZThe MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells10.1038/ncomms117402041-1723https://doaj.org/article/433046fc179446af96ac4977f8bb7b862016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11740https://doaj.org/toc/2041-1723Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate carboxylase, thereby inhibiting insulin secretion.Xiaomu LiKenneth K. Y. ChengZhuohao LiuJin-Kui YangBaile WangXue JiangYawen ZhouPhilip HallenborgRuby L. C. HooKaren S. L. LamYasuhiro IkedaXin GaoAimin XuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xiaomu Li Kenneth K. Y. Cheng Zhuohao Liu Jin-Kui Yang Baile Wang Xue Jiang Yawen Zhou Philip Hallenborg Ruby L. C. Hoo Karen S. L. Lam Yasuhiro Ikeda Xin Gao Aimin Xu The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| description |
Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate carboxylase, thereby inhibiting insulin secretion. |
| format |
article |
| author |
Xiaomu Li Kenneth K. Y. Cheng Zhuohao Liu Jin-Kui Yang Baile Wang Xue Jiang Yawen Zhou Philip Hallenborg Ruby L. C. Hoo Karen S. L. Lam Yasuhiro Ikeda Xin Gao Aimin Xu |
| author_facet |
Xiaomu Li Kenneth K. Y. Cheng Zhuohao Liu Jin-Kui Yang Baile Wang Xue Jiang Yawen Zhou Philip Hallenborg Ruby L. C. Hoo Karen S. L. Lam Yasuhiro Ikeda Xin Gao Aimin Xu |
| author_sort |
Xiaomu Li |
| title |
The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_short |
The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_full |
The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_fullStr |
The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_full_unstemmed |
The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_sort |
mdm2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/433046fc179446af96ac4977f8bb7b86 |
| work_keys_str_mv |
AT xiaomuli themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT kennethkycheng themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT zhuohaoliu themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT jinkuiyang themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT bailewang themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT xuejiang themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT yawenzhou themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT philiphallenborg themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT rubylchoo themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT karensllam themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT yasuhiroikeda themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT xingao themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT aiminxu themdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT xiaomuli mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT kennethkycheng mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT zhuohaoliu mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT jinkuiyang mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT bailewang mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT xuejiang mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT yawenzhou mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT philiphallenborg mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT rubylchoo mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT karensllam mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT yasuhiroikeda mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT xingao mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells AT aiminxu mdm2p53pyruvatecarboxylasesignallingaxiscouplesmitochondrialmetabolismtoglucosestimulatedinsulinsecretioninpancreaticbcells |
| _version_ |
1718386469150654464 |