Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma

Objective To investigate the correlation between cyclin G1 expression and the efficacy of radiotherapy on HCC. Methods The expression of cyclin G1 in biopsy specimens of 68 patients who received radiotherapy was detected by immunochemistry. The correlation between cyclin G1 expression and clinicopat...

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Autores principales:	XU Gang, BU Shanshan, WANG Xiushen, GE Hong
Formato:	article
Lenguaje:	ZH
Publicado:	Magazine House of Cancer Research on Prevention and Treatment 2021
Materias:	cyclin g1 hepatocellular carcinoma radiotherapy prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/43362d926af046b6b7dc3c0552acbcc2
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spelling	oai:doaj.org-article:43362d926af046b6b7dc3c0552acbcc22021-11-05T02:22:52ZCorrelation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma1000-857810.3971/j.issn.1000-8578.2021.21.0316https://doaj.org/article/43362d926af046b6b7dc3c0552acbcc22021-10-01T00:00:00Zhttp://html.rhhz.net/ZLFZYJ/html/8578.2021.21.0316.htmhttps://doaj.org/toc/1000-8578Objective To investigate the correlation between cyclin G1 expression and the efficacy of radiotherapy on HCC. Methods The expression of cyclin G1 in biopsy specimens of 68 patients who received radiotherapy was detected by immunochemistry. The correlation between cyclin G1 expression and clinicopathological characteristics was analyzed by chi-square test. The correlation between cyclin G1 expression and OS or PFS was evaluated by Kaplan-Meier analysis. Univariate and multivariate analyses were used for the relation between clinicopathological characteristics and OS or PFS. Results The expression of cyclin G1 was related to portal vein tumor embolus, clinical stage and alpha fetoprotein. Survival analysis showed that the OS and PFS of patients with low expression of cyclin G1 were significantly higher than those with high cyclin G1 expression (P < 0.05). Multivariate analysis showed that cyclin G1 was an independent risk factor for DFS of patients with HCC. Conclusion High expression of cyclin G1 is an adverse prognostic factor for HCC patients who received radiotherapy.XU GangBU ShanshanWANG XiushenGE HongMagazine House of Cancer Research on Prevention and Treatmentarticlecyclin g1hepatocellular carcinomaradiotherapyprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ZHZhongliu Fangzhi Yanjiu, Vol 48, Iss 10, Pp 958-962 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	cyclin g1 hepatocellular carcinoma radiotherapy prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cyclin g1 hepatocellular carcinoma radiotherapy prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 XU Gang BU Shanshan WANG Xiushen GE Hong Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma
description	Objective To investigate the correlation between cyclin G1 expression and the efficacy of radiotherapy on HCC. Methods The expression of cyclin G1 in biopsy specimens of 68 patients who received radiotherapy was detected by immunochemistry. The correlation between cyclin G1 expression and clinicopathological characteristics was analyzed by chi-square test. The correlation between cyclin G1 expression and OS or PFS was evaluated by Kaplan-Meier analysis. Univariate and multivariate analyses were used for the relation between clinicopathological characteristics and OS or PFS. Results The expression of cyclin G1 was related to portal vein tumor embolus, clinical stage and alpha fetoprotein. Survival analysis showed that the OS and PFS of patients with low expression of cyclin G1 were significantly higher than those with high cyclin G1 expression (P < 0.05). Multivariate analysis showed that cyclin G1 was an independent risk factor for DFS of patients with HCC. Conclusion High expression of cyclin G1 is an adverse prognostic factor for HCC patients who received radiotherapy.
format	article
author	XU Gang BU Shanshan WANG Xiushen GE Hong
author_facet	XU Gang BU Shanshan WANG Xiushen GE Hong
author_sort	XU Gang
title	Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma
title_short	Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma
title_full	Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma
title_fullStr	Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma
title_full_unstemmed	Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma
title_sort	correlation between cyclin g1 expression and efficacy of radiotherapy on primary hepatocellular carcinoma
publisher	Magazine House of Cancer Research on Prevention and Treatment
publishDate	2021
url	https://doaj.org/article/43362d926af046b6b7dc3c0552acbcc2
work_keys_str_mv	AT xugang correlationbetweencycling1expressionandefficacyofradiotherapyonprimaryhepatocellularcarcinoma AT bushanshan correlationbetweencycling1expressionandefficacyofradiotherapyonprimaryhepatocellularcarcinoma AT wangxiushen correlationbetweencycling1expressionandefficacyofradiotherapyonprimaryhepatocellularcarcinoma AT gehong correlationbetweencycling1expressionandefficacyofradiotherapyonprimaryhepatocellularcarcinoma
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Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma

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