Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma

Fabio Lavinsky,1,2 Camila Zanella Benfica,2 Nédio Castoldi,2 Anne Elise Cruz do Carmo Chaves,2 Paulo Augusto de Arruda Mello1 1Department of Ophthalmology, Paulista School of Medicine, São Paulo Hospital, Universidade Federal de São Paulo (UNIFESP), São P...

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Autores principales:	Lavinsky F, Benfica CZ, Castoldi N, Cruz do Carmo Chaves AE, Mello PAA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Glaucoma diagnosis optic nerve head visual fields ocular imaging. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4336bf097dac40abb41357e6ac60b399
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spelling	oai:doaj.org-article:4336bf097dac40abb41357e6ac60b3992021-12-02T10:06:35ZMeasurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma1177-5483https://doaj.org/article/4336bf097dac40abb41357e6ac60b3992018-01-01T00:00:00Zhttps://www.dovepress.com/measurement-of-the-hypotenuse-of-the-vertical-optic-nerve-head-cup-wit-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Fabio Lavinsky,1,2 Camila Zanella Benfica,2 Nédio Castoldi,2 Anne Elise Cruz do Carmo Chaves,2 Paulo Augusto de Arruda Mello1 1Department of Ophthalmology, Paulista School of Medicine, São Paulo Hospital, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; 2Department of Ophthalmology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil Purpose: To evaluate the hypotenuse of the vertical optic nerve head cup (HVOC), measured using the length and depth of the cup obtained with enhanced depth imaging spectral-domain optic coherence tomography (SD-OCT), as a biomarker for glaucoma diagnosis. Methods: This was a prospective cross-sectional study of patients with glaucoma and controls. SD-OCT was performed in all participants to assess average circumpapillary retinal nerve fiber layer (RNFL) thickness. A vertical B-scan of the optic nerve head (ONH) was obtained for HVOC measurement. The length and depth of the optic nerve cup formed the sides of a right triangle that were used to calculate the HVOC. Participants also underwent standard automated perimetry. Results: One hundred and fifty-six eyes were divided into three groups: mean deviation (MD) <-7 dB (60 eyes); MD ≥-7 dB (74 eyes); and healthy subjects (22 eyes). The mean (SD) HVOC in these groups was 1,419.8 (347.2) µm, 1,234.6 (258.8) µm, and 685.79 (315.4) µm (P<0.01), respectively. In the secondary structure–function analysis, only discs with a vertical diameter of 1.51–2.00 mm were included (120 eyes). The HVOCs were divided into four percentile groups, with the following means: 940, 1,128, 1,390, and 1,662 µm. There was a significant difference in MD between percentile groups 1 and 3 (P<0.03), 1 and 4 (P<0.001), 2 and 3 (P<0.02), and 2 and 4 (P<0.001). RNFL thickness differed among all percentile groups (P<0.001). Conclusion: HVOC may provide an additional morphometric biomarker for the structural evaluation of ONH remodeling in glaucoma. Keywords: glaucoma diagnosis, optic nerve head, visual fields, ocular imagingLavinsky FBenfica CZCastoldi NCruz do Carmo Chaves AEMello PAADove Medical PressarticleGlaucoma diagnosisoptic nerve headvisual fieldsocular imaging.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 215-225 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glaucoma diagnosis optic nerve head visual fields ocular imaging. Ophthalmology RE1-994
spellingShingle	Glaucoma diagnosis optic nerve head visual fields ocular imaging. Ophthalmology RE1-994 Lavinsky F Benfica CZ Castoldi N Cruz do Carmo Chaves AE Mello PAA Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma
description	Fabio Lavinsky,1,2 Camila Zanella Benfica,2 Nédio Castoldi,2 Anne Elise Cruz do Carmo Chaves,2 Paulo Augusto de Arruda Mello1 1Department of Ophthalmology, Paulista School of Medicine, São Paulo Hospital, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; 2Department of Ophthalmology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil Purpose: To evaluate the hypotenuse of the vertical optic nerve head cup (HVOC), measured using the length and depth of the cup obtained with enhanced depth imaging spectral-domain optic coherence tomography (SD-OCT), as a biomarker for glaucoma diagnosis. Methods: This was a prospective cross-sectional study of patients with glaucoma and controls. SD-OCT was performed in all participants to assess average circumpapillary retinal nerve fiber layer (RNFL) thickness. A vertical B-scan of the optic nerve head (ONH) was obtained for HVOC measurement. The length and depth of the optic nerve cup formed the sides of a right triangle that were used to calculate the HVOC. Participants also underwent standard automated perimetry. Results: One hundred and fifty-six eyes were divided into three groups: mean deviation (MD) <-7 dB (60 eyes); MD ≥-7 dB (74 eyes); and healthy subjects (22 eyes). The mean (SD) HVOC in these groups was 1,419.8 (347.2) µm, 1,234.6 (258.8) µm, and 685.79 (315.4) µm (P<0.01), respectively. In the secondary structure–function analysis, only discs with a vertical diameter of 1.51–2.00 mm were included (120 eyes). The HVOCs were divided into four percentile groups, with the following means: 940, 1,128, 1,390, and 1,662 µm. There was a significant difference in MD between percentile groups 1 and 3 (P<0.03), 1 and 4 (P<0.001), 2 and 3 (P<0.02), and 2 and 4 (P<0.001). RNFL thickness differed among all percentile groups (P<0.001). Conclusion: HVOC may provide an additional morphometric biomarker for the structural evaluation of ONH remodeling in glaucoma. Keywords: glaucoma diagnosis, optic nerve head, visual fields, ocular imaging
format	article
author	Lavinsky F Benfica CZ Castoldi N Cruz do Carmo Chaves AE Mello PAA
author_facet	Lavinsky F Benfica CZ Castoldi N Cruz do Carmo Chaves AE Mello PAA
author_sort	Lavinsky F
title	Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma
title_short	Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma
title_full	Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma
title_fullStr	Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma
title_full_unstemmed	Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma
title_sort	measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/4336bf097dac40abb41357e6ac60b399
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Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma

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