A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression

Chondrosarcomas are frequently aggressive, understanding the transcriptional changes associated with progression may help in developing new treatments. Here, the authors show that HIF-2α is increased in expression on progression and pharmacological inhibition of the protein together with chemotherap...

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Autores principales:	Hyeonkyeong Kim, Yongsik Cho, Hyeon-Seop Kim, Donghyun Kang, Donghyeon Cheon, Yi-Jun Kim, Moon Jong Chang, Kyoung Min Lee, Chong Bum Chang, Seung-Baik Kang, Hyun Guy Kang, Jin-Hong Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/433db9da38794f3ca4269f360c059b88
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spelling	oai:doaj.org-article:433db9da38794f3ca4269f360c059b882021-12-02T17:13:19ZA system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression10.1038/s41467-020-18817-72041-1723https://doaj.org/article/433db9da38794f3ca4269f360c059b882020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18817-7https://doaj.org/toc/2041-1723Chondrosarcomas are frequently aggressive, understanding the transcriptional changes associated with progression may help in developing new treatments. Here, the authors show that HIF-2α is increased in expression on progression and pharmacological inhibition of the protein together with chemotherapy is a useful strategy for controlling tumour growth in mice.Hyeonkyeong KimYongsik ChoHyeon-Seop KimDonghyun KangDonghyeon CheonYi-Jun KimMoon Jong ChangKyoung Min LeeChong Bum ChangSeung-Baik KangHyun Guy KangJin-Hong KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyeonkyeong Kim Yongsik Cho Hyeon-Seop Kim Donghyun Kang Donghyeon Cheon Yi-Jun Kim Moon Jong Chang Kyoung Min Lee Chong Bum Chang Seung-Baik Kang Hyun Guy Kang Jin-Hong Kim A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression
description	Chondrosarcomas are frequently aggressive, understanding the transcriptional changes associated with progression may help in developing new treatments. Here, the authors show that HIF-2α is increased in expression on progression and pharmacological inhibition of the protein together with chemotherapy is a useful strategy for controlling tumour growth in mice.
format	article
author	Hyeonkyeong Kim Yongsik Cho Hyeon-Seop Kim Donghyun Kang Donghyeon Cheon Yi-Jun Kim Moon Jong Chang Kyoung Min Lee Chong Bum Chang Seung-Baik Kang Hyun Guy Kang Jin-Hong Kim
author_facet	Hyeonkyeong Kim Yongsik Cho Hyeon-Seop Kim Donghyun Kang Donghyeon Cheon Yi-Jun Kim Moon Jong Chang Kyoung Min Lee Chong Bum Chang Seung-Baik Kang Hyun Guy Kang Jin-Hong Kim
author_sort	Hyeonkyeong Kim
title	A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression
title_short	A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression
title_full	A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression
title_fullStr	A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression
title_full_unstemmed	A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression
title_sort	system-level approach identifies hif-2α as a critical regulator of chondrosarcoma progression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/433db9da38794f3ca4269f360c059b88
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A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression

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