Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks

DNA double-strand break (DSB) leads to genome rearrangements with various genetic and phenotypic effects. Here, the authors develop a tool to induce large-scale genome restructuring by introducing conditional multiple DNA breaks, and produce various traits in yeast and Arabidopsis thaliana.

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Autores principales:	Nobuhiko Muramoto, Arisa Oda, Hidenori Tanaka, Takahiro Nakamura, Kazuto Kugou, Kazuki Suda, Aki Kobayashi, Shiori Yoneda, Akinori Ikeuchi, Hiroki Sugimoto, Satoshi Kondo, Chikara Ohto, Takehiko Shibata, Norihiro Mitsukawa, Kunihiro Ohta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/434e993b418749de9945d96b490b9178
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spelling	oai:doaj.org-article:434e993b418749de9945d96b490b91782021-12-02T14:40:43ZPhenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks10.1038/s41467-018-04256-y2041-1723https://doaj.org/article/434e993b418749de9945d96b490b91782018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04256-yhttps://doaj.org/toc/2041-1723DNA double-strand break (DSB) leads to genome rearrangements with various genetic and phenotypic effects. Here, the authors develop a tool to induce large-scale genome restructuring by introducing conditional multiple DNA breaks, and produce various traits in yeast and Arabidopsis thaliana.Nobuhiko MuramotoArisa OdaHidenori TanakaTakahiro NakamuraKazuto KugouKazuki SudaAki KobayashiShiori YonedaAkinori IkeuchiHiroki SugimotoSatoshi KondoChikara OhtoTakehiko ShibataNorihiro MitsukawaKunihiro OhtaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nobuhiko Muramoto Arisa Oda Hidenori Tanaka Takahiro Nakamura Kazuto Kugou Kazuki Suda Aki Kobayashi Shiori Yoneda Akinori Ikeuchi Hiroki Sugimoto Satoshi Kondo Chikara Ohto Takehiko Shibata Norihiro Mitsukawa Kunihiro Ohta Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks
description	DNA double-strand break (DSB) leads to genome rearrangements with various genetic and phenotypic effects. Here, the authors develop a tool to induce large-scale genome restructuring by introducing conditional multiple DNA breaks, and produce various traits in yeast and Arabidopsis thaliana.
format	article
author	Nobuhiko Muramoto Arisa Oda Hidenori Tanaka Takahiro Nakamura Kazuto Kugou Kazuki Suda Aki Kobayashi Shiori Yoneda Akinori Ikeuchi Hiroki Sugimoto Satoshi Kondo Chikara Ohto Takehiko Shibata Norihiro Mitsukawa Kunihiro Ohta
author_facet	Nobuhiko Muramoto Arisa Oda Hidenori Tanaka Takahiro Nakamura Kazuto Kugou Kazuki Suda Aki Kobayashi Shiori Yoneda Akinori Ikeuchi Hiroki Sugimoto Satoshi Kondo Chikara Ohto Takehiko Shibata Norihiro Mitsukawa Kunihiro Ohta
author_sort	Nobuhiko Muramoto
title	Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks
title_short	Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks
title_full	Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks
title_fullStr	Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks
title_full_unstemmed	Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks
title_sort	phenotypic diversification by enhanced genome restructuring after induction of multiple dna double-strand breaks
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/434e993b418749de9945d96b490b9178
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Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks

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