Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria

Mitochondrial Ca2+ homoeostasis is tightly regulated and export of Ca2+ is mediated by an Na+Ca2+ exchanger. Here authors show that in depolarised mitochondria the exchanger initially operates in reverse mode, transporting cytosolic Ca2+ into the matrix before it reverts to its forward mode state.

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Autores principales:	Krishna Samanta, Gary R. Mirams, Anant B. Parekh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/434eb1455b9249acb8d848b2a2c21c00
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spelling	oai:doaj.org-article:434eb1455b9249acb8d848b2a2c21c002021-12-02T14:39:45ZSequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria10.1038/s41467-017-02638-22041-1723https://doaj.org/article/434eb1455b9249acb8d848b2a2c21c002018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02638-2https://doaj.org/toc/2041-1723Mitochondrial Ca2+ homoeostasis is tightly regulated and export of Ca2+ is mediated by an Na+Ca2+ exchanger. Here authors show that in depolarised mitochondria the exchanger initially operates in reverse mode, transporting cytosolic Ca2+ into the matrix before it reverts to its forward mode state.Krishna SamantaGary R. MiramsAnant B. ParekhNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishna Samanta Gary R. Mirams Anant B. Parekh Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
description	Mitochondrial Ca2+ homoeostasis is tightly regulated and export of Ca2+ is mediated by an Na+Ca2+ exchanger. Here authors show that in depolarised mitochondria the exchanger initially operates in reverse mode, transporting cytosolic Ca2+ into the matrix before it reverts to its forward mode state.
format	article
author	Krishna Samanta Gary R. Mirams Anant B. Parekh
author_facet	Krishna Samanta Gary R. Mirams Anant B. Parekh
author_sort	Krishna Samanta
title	Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
title_short	Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
title_full	Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
title_fullStr	Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
title_full_unstemmed	Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
title_sort	sequential forward and reverse transport of the na+ ca2+ exchanger generates ca2+ oscillations within mitochondria
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/434eb1455b9249acb8d848b2a2c21c00
work_keys_str_mv	AT krishnasamanta sequentialforwardandreversetransportofthenaca2exchangergeneratesca2oscillationswithinmitochondria AT garyrmirams sequentialforwardandreversetransportofthenaca2exchangergeneratesca2oscillationswithinmitochondria AT anantbparekh sequentialforwardandreversetransportofthenaca2exchangergeneratesca2oscillationswithinmitochondria
_version_	1718390528117047296

Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria

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