EVALUATION OF THE in vitro ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES Caryodendron orinocense AND Phyllanthus niruri FROM Euphorbiaceae FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 1

Viruses cause human and animal diseases of both epidemiological and economic importance and for many of them there are no satisfactory treatments or resistant strains are generated during drug therapy. Extracts from the Euphorbiaceae family plants have shown activity against viruses belonging to the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	David ARBOLEDA C., Ana L. CAÑAS O., Albeiro LÓPEZ H., Jorge E. FORERO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Caryodendron orinocense Phyllanthus niruri herpes simplex virus type 2 herpes bovine virus Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/434fd14f667640689c4fa8ddddf7bcd9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:434fd14f667640689c4fa8ddddf7bcd9
record_format	dspace
spelling	oai:doaj.org-article:434fd14f667640689c4fa8ddddf7bcd92021-11-19T04:21:32ZEVALUATION OF THE <I>in vitro</I> ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES <I>Caryodendron orinocense</I> AND <I>Phyllanthus niruri</I> FROM <I>Euphorbiaceae</I> FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 10121-40042145-2660https://doaj.org/article/434fd14f667640689c4fa8ddddf7bcd92009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/575https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Viruses cause human and animal diseases of both epidemiological and economic importance and for many of them there are no satisfactory treatments or resistant strains are generated during drug therapy. Extracts from the Euphorbiaceae family plants have shown activity against viruses belonging to the Herpesviridae family. Both the toxicity and the antiviral activity of hexanic, ethyl acetate, methanolic and aqueous extracts from the Euphorbiaceae species Caryodendron orinocense and Phyllanthus niruri against Herpes Simplex Virus type 2 and Herpes Bovine Virus type 1, were evaluated using the crystal violet plaque staining technique. Furthermore, a preliminary phytochemical study of both species is presented. In general, extracts from the studied species showed toxic concentrations higher than 250 μg/ml. The ethyl acetate extract from Caryodendron orinocense showed the greatest viral reduction factor for both HSV-2 and HVB-1, namely, 102 at a concentration of 125 μg/ml and 104 a 62.5 μg/ml, respectively. The studied species showed a chemical composition determined primarily by aminoacids, phenolic compounds, tanins and triterpenes,metabolites that could be involved in their antiviral activity. David ARBOLEDA C.Ana L. CAÑAS O.Albeiro LÓPEZ H.Jorge E. FOREROUniversidad de AntioquiaarticleCaryodendron orinocensePhyllanthus niruriherpes simplex virus type 2herpes bovine virusFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Caryodendron orinocense Phyllanthus niruri herpes simplex virus type 2 herpes bovine virus Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Caryodendron orinocense Phyllanthus niruri herpes simplex virus type 2 herpes bovine virus Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 David ARBOLEDA C. Ana L. CAÑAS O. Albeiro LÓPEZ H. Jorge E. FORERO EVALUATION OF THE <I>in vitro</I> ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES <I>Caryodendron orinocense</I> AND <I>Phyllanthus niruri</I> FROM <I>Euphorbiaceae</I> FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 1
description	Viruses cause human and animal diseases of both epidemiological and economic importance and for many of them there are no satisfactory treatments or resistant strains are generated during drug therapy. Extracts from the Euphorbiaceae family plants have shown activity against viruses belonging to the Herpesviridae family. Both the toxicity and the antiviral activity of hexanic, ethyl acetate, methanolic and aqueous extracts from the Euphorbiaceae species Caryodendron orinocense and Phyllanthus niruri against Herpes Simplex Virus type 2 and Herpes Bovine Virus type 1, were evaluated using the crystal violet plaque staining technique. Furthermore, a preliminary phytochemical study of both species is presented. In general, extracts from the studied species showed toxic concentrations higher than 250 μg/ml. The ethyl acetate extract from Caryodendron orinocense showed the greatest viral reduction factor for both HSV-2 and HVB-1, namely, 102 at a concentration of 125 μg/ml and 104 a 62.5 μg/ml, respectively. The studied species showed a chemical composition determined primarily by aminoacids, phenolic compounds, tanins and triterpenes,metabolites that could be involved in their antiviral activity.
format	article
author	David ARBOLEDA C. Ana L. CAÑAS O. Albeiro LÓPEZ H. Jorge E. FORERO
author_facet	David ARBOLEDA C. Ana L. CAÑAS O. Albeiro LÓPEZ H. Jorge E. FORERO
author_sort	David ARBOLEDA C.
title	EVALUATION OF THE <I>in vitro</I> ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES <I>Caryodendron orinocense</I> AND <I>Phyllanthus niruri</I> FROM <I>Euphorbiaceae</I> FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 1
title_short	EVALUATION OF THE <I>in vitro</I> ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES <I>Caryodendron orinocense</I> AND <I>Phyllanthus niruri</I> FROM <I>Euphorbiaceae</I> FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 1
title_full	EVALUATION OF THE <I>in vitro</I> ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES <I>Caryodendron orinocense</I> AND <I>Phyllanthus niruri</I> FROM <I>Euphorbiaceae</I> FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 1
title_fullStr	EVALUATION OF THE <I>in vitro</I> ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES <I>Caryodendron orinocense</I> AND <I>Phyllanthus niruri</I> FROM <I>Euphorbiaceae</I> FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 1
title_full_unstemmed	EVALUATION OF THE <I>in vitro</I> ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES <I>Caryodendron orinocense</I> AND <I>Phyllanthus niruri</I> FROM <I>Euphorbiaceae</I> FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 1
title_sort	evaluation of the <i>in vitro</i> antiviral activity of four extracts from the species <i>caryodendron orinocense</i> and <i>phyllanthus niruri</i> from <i>euphorbiaceae</i> family against herpes simplex virus type 2 and bovine herpes virus type 1
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/434fd14f667640689c4fa8ddddf7bcd9
work_keys_str_mv	AT davidarboledac evaluationoftheiinvitroiantiviralactivityoffourextractsfromthespeciesicaryodendronorinocenseiandiphyllanthusniruriifromieuphorbiaceaeifamilyagainstherpessimplexvirustype2andbovineherpesvirustype1 AT analcanaso evaluationoftheiinvitroiantiviralactivityoffourextractsfromthespeciesicaryodendronorinocenseiandiphyllanthusniruriifromieuphorbiaceaeifamilyagainstherpessimplexvirustype2andbovineherpesvirustype1 AT albeirolopezh evaluationoftheiinvitroiantiviralactivityoffourextractsfromthespeciesicaryodendronorinocenseiandiphyllanthusniruriifromieuphorbiaceaeifamilyagainstherpessimplexvirustype2andbovineherpesvirustype1 AT jorgeeforero evaluationoftheiinvitroiantiviralactivityoffourextractsfromthespeciesicaryodendronorinocenseiandiphyllanthusniruriifromieuphorbiaceaeifamilyagainstherpessimplexvirustype2andbovineherpesvirustype1
_version_	1718420423289339904

EVALUATION OF THE <I>in vitro</I> ANTIVIRAL ACTIVITY OF FOUR EXTRACTS FROM THE SPECIES <I>Caryodendron orinocense</I> AND <I>Phyllanthus niruri</I> FROM <I>Euphorbiaceae</I> FAMILY AGAINST HERPES SIMPLEX VIRUS TYPE 2 AND BOVINE HERPES VIRUS TYPE 1

Ejemplares similares