Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge

Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge

Plasma cells produce secreted antibodies and are thought to lack expression of the membrane-bound immunoglobulins that constitute B-cell receptors. Here the authors show that IgM-expressing plasma cells maintain B-cell receptor expression and initiate cytokine production following antigen stimulatio...

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Main Authors: Pascal Blanc, Ludovic Moro-Sibilot, Lucas Barthly, Ferdinand Jagot, Sébastien This, Simon de Bernard, Laurent Buffat, Sébastien Dussurgey, Renaud Colisson, Elias Hobeika, Thierry Fest, Morgan Taillardet, Olivier Thaunat, Antoine Sicard, Paul Mondière, Laurent Genestier, Stephen L. Nutt, Thierry Defrance
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/4350b0308b6a4d4695c4d9c986d6a9f1
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Summary:Plasma cells produce secreted antibodies and are thought to lack expression of the membrane-bound immunoglobulins that constitute B-cell receptors. Here the authors show that IgM-expressing plasma cells maintain B-cell receptor expression and initiate cytokine production following antigen stimulation.

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