Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge

Plasma cells produce secreted antibodies and are thought to lack expression of the membrane-bound immunoglobulins that constitute B-cell receptors. Here the authors show that IgM-expressing plasma cells maintain B-cell receptor expression and initiate cytokine production following antigen stimulatio...

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Autores principales:	Pascal Blanc, Ludovic Moro-Sibilot, Lucas Barthly, Ferdinand Jagot, Sébastien This, Simon de Bernard, Laurent Buffat, Sébastien Dussurgey, Renaud Colisson, Elias Hobeika, Thierry Fest, Morgan Taillardet, Olivier Thaunat, Antoine Sicard, Paul Mondière, Laurent Genestier, Stephen L. Nutt, Thierry Defrance
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4350b0308b6a4d4695c4d9c986d6a9f1
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spelling	oai:doaj.org-article:4350b0308b6a4d4695c4d9c986d6a9f12021-12-02T16:57:05ZMature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge10.1038/ncomms136002041-1723https://doaj.org/article/4350b0308b6a4d4695c4d9c986d6a9f12016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13600https://doaj.org/toc/2041-1723Plasma cells produce secreted antibodies and are thought to lack expression of the membrane-bound immunoglobulins that constitute B-cell receptors. Here the authors show that IgM-expressing plasma cells maintain B-cell receptor expression and initiate cytokine production following antigen stimulation.Pascal BlancLudovic Moro-SibilotLucas BarthlyFerdinand JagotSébastien ThisSimon de BernardLaurent BuffatSébastien DussurgeyRenaud ColissonElias HobeikaThierry FestMorgan TaillardetOlivier ThaunatAntoine SicardPaul MondièreLaurent GenestierStephen L. NuttThierry DefranceNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pascal Blanc Ludovic Moro-Sibilot Lucas Barthly Ferdinand Jagot Sébastien This Simon de Bernard Laurent Buffat Sébastien Dussurgey Renaud Colisson Elias Hobeika Thierry Fest Morgan Taillardet Olivier Thaunat Antoine Sicard Paul Mondière Laurent Genestier Stephen L. Nutt Thierry Defrance Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge
description	Plasma cells produce secreted antibodies and are thought to lack expression of the membrane-bound immunoglobulins that constitute B-cell receptors. Here the authors show that IgM-expressing plasma cells maintain B-cell receptor expression and initiate cytokine production following antigen stimulation.
format	article
author	Pascal Blanc Ludovic Moro-Sibilot Lucas Barthly Ferdinand Jagot Sébastien This Simon de Bernard Laurent Buffat Sébastien Dussurgey Renaud Colisson Elias Hobeika Thierry Fest Morgan Taillardet Olivier Thaunat Antoine Sicard Paul Mondière Laurent Genestier Stephen L. Nutt Thierry Defrance
author_facet	Pascal Blanc Ludovic Moro-Sibilot Lucas Barthly Ferdinand Jagot Sébastien This Simon de Bernard Laurent Buffat Sébastien Dussurgey Renaud Colisson Elias Hobeika Thierry Fest Morgan Taillardet Olivier Thaunat Antoine Sicard Paul Mondière Laurent Genestier Stephen L. Nutt Thierry Defrance
author_sort	Pascal Blanc
title	Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge
title_short	Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge
title_full	Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge
title_fullStr	Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge
title_full_unstemmed	Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge
title_sort	mature igm-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4350b0308b6a4d4695c4d9c986d6a9f1
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Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge

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