Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma

Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma

Abstract The incidence and mortality rates of intrahepatic cholangiocarcinoma have been rising worldwide. Few patients present an early-stage disease that is amenable to curative surgery and after resection, high recurrence rates persist. To identify new independent marker related to aggressive beha...

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Main Authors: Michele Simbolo, Caterina Vicentini, Andrea Ruzzenente, Matteo Brunelli, Simone Conci, Matteo Fassan, Andrea Mafficini, Borislav Rusev, Vincenzo Corbo, Paola Capelli, Emilio Bria, Serena Pedron, Giona Turri, Rita T. Lawlor, Giampaolo Tortora, Claudio Bassi, Alfredo Guglielmi, Aldo Scarpa
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/43514a3462ab48c3877101c0b0918453
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