Exosomes in chronic respiratory diseases

Exosomes are nano-sized vesicles released by almost all cell types, with a central role as mediators of intercellular communication. In addition to physiological conditions, these extracellular vesicles seem to play a pivotal role in inflammatory processes. This assumption offers the opportunity to...

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Autores principales:	Beatrice Purghè, Marcello Manfredi, Beatrice Ragnoli, Gianluca Baldanzi, Mario Malerba
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Exosomes Biological fluid Chronic respiratory disease Biomarker Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/43516ec509014b208004a5cacc5922f6
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spelling	oai:doaj.org-article:43516ec509014b208004a5cacc5922f62021-11-14T04:29:05ZExosomes in chronic respiratory diseases0753-332210.1016/j.biopha.2021.112270https://doaj.org/article/43516ec509014b208004a5cacc5922f62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010544https://doaj.org/toc/0753-3322Exosomes are nano-sized vesicles released by almost all cell types, with a central role as mediators of intercellular communication. In addition to physiological conditions, these extracellular vesicles seem to play a pivotal role in inflammatory processes. This assumption offers the opportunity to study exosomes as promising biomarkers and therapeutic tools for chronic respiratory disorders. Indeed, although it is well-known that at the basis of conditions like asthma, chronic obstructive pulmonary disease, alpha-1 antitrypsin deficiency and idiopathic pulmonary fibrosis there is a dysregulated inflammatory process, an unequivocal correlation between different phenotypes and their pathophysiological mechanisms has not been established yet. In this review, we report and discuss some of the most significant studies on exosomes from body fluids of subjects affected by airway diseases. Furthermore, the most widespread techniques for exosome isolation and characterization are described. Further studies are needed to answer the unresolved questions about the functional link between exosomes and chronic respiratory diseases.Beatrice PurghèMarcello ManfrediBeatrice RagnoliGianluca BaldanziMario MalerbaElsevierarticleExosomesBiological fluidChronic respiratory diseaseBiomarkerTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112270- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Exosomes Biological fluid Chronic respiratory disease Biomarker Therapeutics. Pharmacology RM1-950
spellingShingle	Exosomes Biological fluid Chronic respiratory disease Biomarker Therapeutics. Pharmacology RM1-950 Beatrice Purghè Marcello Manfredi Beatrice Ragnoli Gianluca Baldanzi Mario Malerba Exosomes in chronic respiratory diseases
description	Exosomes are nano-sized vesicles released by almost all cell types, with a central role as mediators of intercellular communication. In addition to physiological conditions, these extracellular vesicles seem to play a pivotal role in inflammatory processes. This assumption offers the opportunity to study exosomes as promising biomarkers and therapeutic tools for chronic respiratory disorders. Indeed, although it is well-known that at the basis of conditions like asthma, chronic obstructive pulmonary disease, alpha-1 antitrypsin deficiency and idiopathic pulmonary fibrosis there is a dysregulated inflammatory process, an unequivocal correlation between different phenotypes and their pathophysiological mechanisms has not been established yet. In this review, we report and discuss some of the most significant studies on exosomes from body fluids of subjects affected by airway diseases. Furthermore, the most widespread techniques for exosome isolation and characterization are described. Further studies are needed to answer the unresolved questions about the functional link between exosomes and chronic respiratory diseases.
format	article
author	Beatrice Purghè Marcello Manfredi Beatrice Ragnoli Gianluca Baldanzi Mario Malerba
author_facet	Beatrice Purghè Marcello Manfredi Beatrice Ragnoli Gianluca Baldanzi Mario Malerba
author_sort	Beatrice Purghè
title	Exosomes in chronic respiratory diseases
title_short	Exosomes in chronic respiratory diseases
title_full	Exosomes in chronic respiratory diseases
title_fullStr	Exosomes in chronic respiratory diseases
title_full_unstemmed	Exosomes in chronic respiratory diseases
title_sort	exosomes in chronic respiratory diseases
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/43516ec509014b208004a5cacc5922f6
work_keys_str_mv	AT beatricepurghe exosomesinchronicrespiratorydiseases AT marcellomanfredi exosomesinchronicrespiratorydiseases AT beatriceragnoli exosomesinchronicrespiratorydiseases AT gianlucabaldanzi exosomesinchronicrespiratorydiseases AT mariomalerba exosomesinchronicrespiratorydiseases
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Exosomes in chronic respiratory diseases

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