Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice

Abstract Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how social hierarchy in standard group-housed conditions affects behaviour and gene expression in male mice. Four male C57BL/6 mice were kept in each cage used in the...

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Autores principales:	Yasuyuki Horii, Tatsuhiro Nagasawa, Hiroyuki Sakakibara, Aki Takahashi, Akira Tanave, Yuki Matsumoto, Hiromichi Nagayama, Kazuto Yoshimi, Michiko T. Yasuda, Kayoko Shimoi, Tsuyoshi Koide
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/435437b903ad42debd7f2c52b436c5aa
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spelling	oai:doaj.org-article:435437b903ad42debd7f2c52b436c5aa2021-12-02T16:06:14ZHierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice10.1038/s41598-017-07233-52045-2322https://doaj.org/article/435437b903ad42debd7f2c52b436c5aa2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07233-5https://doaj.org/toc/2045-2322Abstract Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how social hierarchy in standard group-housed conditions affects behaviour and gene expression in male mice. Four male C57BL/6 mice were kept in each cage used in the study, and the social hierarchy was determined from observation of video recordings of aggressive behaviour. After formation of a social hierarchy, the behaviour and hippocampal gene expression were analysed in the mice. Higher anxiety- and depression-like behaviours and elevated gene expression of hypothalamic corticotropin-releasing hormone and hippocampal serotonin receptor subtypes were observed in subordinate mice compared with those of dominant mice. These differences were alleviated by orally administering fluoxetine, which is an antidepressant of the selective serotonin reuptake inhibitor class. We concluded that hierarchy in the home cage affects behaviour and gene expression in male mice, resulting in anxiety- and depression-like behaviours being regulated differently in dominant and subordinate mice.Yasuyuki HoriiTatsuhiro NagasawaHiroyuki SakakibaraAki TakahashiAkira TanaveYuki MatsumotoHiromichi NagayamaKazuto YoshimiMichiko T. YasudaKayoko ShimoiTsuyoshi KoideNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasuyuki Horii Tatsuhiro Nagasawa Hiroyuki Sakakibara Aki Takahashi Akira Tanave Yuki Matsumoto Hiromichi Nagayama Kazuto Yoshimi Michiko T. Yasuda Kayoko Shimoi Tsuyoshi Koide Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice
description	Abstract Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how social hierarchy in standard group-housed conditions affects behaviour and gene expression in male mice. Four male C57BL/6 mice were kept in each cage used in the study, and the social hierarchy was determined from observation of video recordings of aggressive behaviour. After formation of a social hierarchy, the behaviour and hippocampal gene expression were analysed in the mice. Higher anxiety- and depression-like behaviours and elevated gene expression of hypothalamic corticotropin-releasing hormone and hippocampal serotonin receptor subtypes were observed in subordinate mice compared with those of dominant mice. These differences were alleviated by orally administering fluoxetine, which is an antidepressant of the selective serotonin reuptake inhibitor class. We concluded that hierarchy in the home cage affects behaviour and gene expression in male mice, resulting in anxiety- and depression-like behaviours being regulated differently in dominant and subordinate mice.
format	article
author	Yasuyuki Horii Tatsuhiro Nagasawa Hiroyuki Sakakibara Aki Takahashi Akira Tanave Yuki Matsumoto Hiromichi Nagayama Kazuto Yoshimi Michiko T. Yasuda Kayoko Shimoi Tsuyoshi Koide
author_facet	Yasuyuki Horii Tatsuhiro Nagasawa Hiroyuki Sakakibara Aki Takahashi Akira Tanave Yuki Matsumoto Hiromichi Nagayama Kazuto Yoshimi Michiko T. Yasuda Kayoko Shimoi Tsuyoshi Koide
author_sort	Yasuyuki Horii
title	Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice
title_short	Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice
title_full	Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice
title_fullStr	Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice
title_full_unstemmed	Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice
title_sort	hierarchy in the home cage affects behaviour and gene expression in group-housed c57bl/6 male mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/435437b903ad42debd7f2c52b436c5aa
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Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice

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