Trained immunity modulates inflammation-induced fibrosis

Innate immune cells can be trained by some stimuli or pathogen exposures to be metabolically and epigenetically altered such that they have different responses to subsequent exposures. Here the authors show that low-dose LPS trained macrophages and BCG-trained macrophages have opposing effects on fi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohamed Jeljeli, Luiza Gama Coelho Riccio, Ludivine Doridot, Charlotte Chêne, Carole Nicco, Sandrine Chouzenoux, Quentin Deletang, Yannick Allanore, Niloufar Kavian, Frédéric Batteux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43548372ff594d5ca49de546cec97da2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:43548372ff594d5ca49de546cec97da2
record_format	dspace
spelling	oai:doaj.org-article:43548372ff594d5ca49de546cec97da22021-12-02T17:01:54ZTrained immunity modulates inflammation-induced fibrosis10.1038/s41467-019-13636-x2041-1723https://doaj.org/article/43548372ff594d5ca49de546cec97da22019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13636-xhttps://doaj.org/toc/2041-1723Innate immune cells can be trained by some stimuli or pathogen exposures to be metabolically and epigenetically altered such that they have different responses to subsequent exposures. Here the authors show that low-dose LPS trained macrophages and BCG-trained macrophages have opposing effects on fibrosis and inflammation in the context of systemic sclerosis.Mohamed JeljeliLuiza Gama Coelho RiccioLudivine DoridotCharlotte ChêneCarole NiccoSandrine ChouzenouxQuentin DeletangYannick AllanoreNiloufar KavianFrédéric BatteuxNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohamed Jeljeli Luiza Gama Coelho Riccio Ludivine Doridot Charlotte Chêne Carole Nicco Sandrine Chouzenoux Quentin Deletang Yannick Allanore Niloufar Kavian Frédéric Batteux Trained immunity modulates inflammation-induced fibrosis
description	Innate immune cells can be trained by some stimuli or pathogen exposures to be metabolically and epigenetically altered such that they have different responses to subsequent exposures. Here the authors show that low-dose LPS trained macrophages and BCG-trained macrophages have opposing effects on fibrosis and inflammation in the context of systemic sclerosis.
format	article
author	Mohamed Jeljeli Luiza Gama Coelho Riccio Ludivine Doridot Charlotte Chêne Carole Nicco Sandrine Chouzenoux Quentin Deletang Yannick Allanore Niloufar Kavian Frédéric Batteux
author_facet	Mohamed Jeljeli Luiza Gama Coelho Riccio Ludivine Doridot Charlotte Chêne Carole Nicco Sandrine Chouzenoux Quentin Deletang Yannick Allanore Niloufar Kavian Frédéric Batteux
author_sort	Mohamed Jeljeli
title	Trained immunity modulates inflammation-induced fibrosis
title_short	Trained immunity modulates inflammation-induced fibrosis
title_full	Trained immunity modulates inflammation-induced fibrosis
title_fullStr	Trained immunity modulates inflammation-induced fibrosis
title_full_unstemmed	Trained immunity modulates inflammation-induced fibrosis
title_sort	trained immunity modulates inflammation-induced fibrosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/43548372ff594d5ca49de546cec97da2
work_keys_str_mv	AT mohamedjeljeli trainedimmunitymodulatesinflammationinducedfibrosis AT luizagamacoelhoriccio trainedimmunitymodulatesinflammationinducedfibrosis AT ludivinedoridot trainedimmunitymodulatesinflammationinducedfibrosis AT charlottechene trainedimmunitymodulatesinflammationinducedfibrosis AT carolenicco trainedimmunitymodulatesinflammationinducedfibrosis AT sandrinechouzenoux trainedimmunitymodulatesinflammationinducedfibrosis AT quentindeletang trainedimmunitymodulatesinflammationinducedfibrosis AT yannickallanore trainedimmunitymodulatesinflammationinducedfibrosis AT niloufarkavian trainedimmunitymodulatesinflammationinducedfibrosis AT fredericbatteux trainedimmunitymodulatesinflammationinducedfibrosis
_version_	1718382024240136192

Trained immunity modulates inflammation-induced fibrosis

Ejemplares similares