ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity

Maria Giovanna Garone et al. use iPSC and mouse models to evaluate a mechanistic link between aberrant axonal phenotypes in ALS and the alteration of a cross-regulatory circuitry involving three RNA binding proteins: FUS, HuD and FMRP. Their results suggest NRN1 as a potential therapeutic target for...

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Autores principales:	Maria Giovanna Garone, Nicol Birsa, Maria Rosito, Federico Salaris, Michela Mochi, Valeria de Turris, Remya R. Nair, Thomas J. Cunningham, Elizabeth M. C. Fisher, Mariangela Morlando, Pietro Fratta, Alessandro Rosa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4355909082b145b69e7ada11d6280eeb
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spelling	oai:doaj.org-article:4355909082b145b69e7ada11d6280eeb2021-12-02T16:38:23ZALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity10.1038/s42003-021-02538-82399-3642https://doaj.org/article/4355909082b145b69e7ada11d6280eeb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02538-8https://doaj.org/toc/2399-3642Maria Giovanna Garone et al. use iPSC and mouse models to evaluate a mechanistic link between aberrant axonal phenotypes in ALS and the alteration of a cross-regulatory circuitry involving three RNA binding proteins: FUS, HuD and FMRP. Their results suggest NRN1 as a potential therapeutic target for ALS and provide further insight into the pathogenesis of this critical disorder.Maria Giovanna GaroneNicol BirsaMaria RositoFederico SalarisMichela MochiValeria de TurrisRemya R. NairThomas J. CunninghamElizabeth M. C. FisherMariangela MorlandoPietro FrattaAlessandro RosaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maria Giovanna Garone Nicol Birsa Maria Rosito Federico Salaris Michela Mochi Valeria de Turris Remya R. Nair Thomas J. Cunningham Elizabeth M. C. Fisher Mariangela Morlando Pietro Fratta Alessandro Rosa ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
description	Maria Giovanna Garone et al. use iPSC and mouse models to evaluate a mechanistic link between aberrant axonal phenotypes in ALS and the alteration of a cross-regulatory circuitry involving three RNA binding proteins: FUS, HuD and FMRP. Their results suggest NRN1 as a potential therapeutic target for ALS and provide further insight into the pathogenesis of this critical disorder.
format	article
author	Maria Giovanna Garone Nicol Birsa Maria Rosito Federico Salaris Michela Mochi Valeria de Turris Remya R. Nair Thomas J. Cunningham Elizabeth M. C. Fisher Mariangela Morlando Pietro Fratta Alessandro Rosa
author_facet	Maria Giovanna Garone Nicol Birsa Maria Rosito Federico Salaris Michela Mochi Valeria de Turris Remya R. Nair Thomas J. Cunningham Elizabeth M. C. Fisher Mariangela Morlando Pietro Fratta Alessandro Rosa
author_sort	Maria Giovanna Garone
title	ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
title_short	ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
title_full	ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
title_fullStr	ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
title_full_unstemmed	ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
title_sort	als-related fus mutations alter axon growth in motoneurons and affect hud/elavl4 and fmrp activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4355909082b145b69e7ada11d6280eeb
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ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity

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