After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation

Intermittent theta-burst stimulation (iTBS) using transcranial magnetic stimulation (TMS) is known to produce excitatory after-effects over the primary motor cortex (M1). Recently, transcranial alternating current stimulation (tACS) at 10 Hz (α) and 20 Hz (β) have been shown to modulate M1 excitabil...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katsuya Ogata, Hisato Nakazono, Takuro Ikeda, Shin-ichiro Oka, Yoshinobu Goto, Shozo Tobimatsu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	transcranial alternating current stimulation transcranial magnetic stimulation primary motor cortex motor evoked potentials intermittent theta burst stimulation phase dependency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/435859eead044441a986838e2e9d5ba5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:435859eead044441a986838e2e9d5ba5
record_format	dspace
spelling	oai:doaj.org-article:435859eead044441a986838e2e9d5ba52021-11-12T05:13:00ZAfter-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation1662-516110.3389/fnhum.2021.750329https://doaj.org/article/435859eead044441a986838e2e9d5ba52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.750329/fullhttps://doaj.org/toc/1662-5161Intermittent theta-burst stimulation (iTBS) using transcranial magnetic stimulation (TMS) is known to produce excitatory after-effects over the primary motor cortex (M1). Recently, transcranial alternating current stimulation (tACS) at 10 Hz (α) and 20 Hz (β) have been shown to modulate M1 excitability in a phase-dependent manner. Therefore, we hypothesized that tACS would modulate the after-effects of iTBS depending on the stimulation frequency and phase. To test our hypothesis, we examined the effects of α- and β-tACS on iTBS using motor evoked potentials (MEPs). Eighteen and thirteen healthy participants were recruited for α and β tACS conditions, respectively. tACS electrodes were attached over the left M1 and Pz. iTBS over left M1 was performed concurrently with tACS. The first pulse of the triple-pulse burst of iTBS was controlled to match the peak (90°) or trough (270°) phase of the tACS. A sham tACS condition was used as a control in which iTBS was administered without tACS. Thus, each participant was tested in three conditions: the peak and trough of the tACS phases and sham tACS. As a result, MEPs were enhanced after iTBS without tACS (sham condition), as observed in previous studies. α-tACS suppressed iTBS effects at the peak phase but not at the trough phase, while β-tACS suppressed the effects at both phases. Thus, although both types of tACS inhibited the facilitatory effects of iTBS, only α-tACS did so in a phase-dependent manner. Phase-dependent inhibition by α-tACS is analogous to our previous finding in which α-tACS inhibited MEPs online at the peak condition. Conversely, β-tACS reduced the effects of iTBS irrespective of its phase. The coupling of brain oscillations and tACS rhythms is considered important in the generation of spike-timing-dependent plasticity. Additionally, the coupling of θ and γ oscillations is assumed to be important for iTBS induction through long-term potentiation (LTP). Therefore, excessive coupling between β oscillations induced by tACS and γ or θ oscillations induced by iTBS might disturb the coupling of θ and γ oscillations during iTBS. To conclude, the action of iTBS is differentially modulated by neuronal oscillations depending on whether α- or β-tACS is applied.Katsuya OgataHisato NakazonoTakuro IkedaShin-ichiro OkaYoshinobu GotoShozo TobimatsuFrontiers Media S.A.articletranscranial alternating current stimulationtranscranial magnetic stimulationprimary motor cortexmotor evoked potentialsintermittent theta burst stimulationphase dependencyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transcranial alternating current stimulation transcranial magnetic stimulation primary motor cortex motor evoked potentials intermittent theta burst stimulation phase dependency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	transcranial alternating current stimulation transcranial magnetic stimulation primary motor cortex motor evoked potentials intermittent theta burst stimulation phase dependency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Katsuya Ogata Hisato Nakazono Takuro Ikeda Shin-ichiro Oka Yoshinobu Goto Shozo Tobimatsu After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation
description	Intermittent theta-burst stimulation (iTBS) using transcranial magnetic stimulation (TMS) is known to produce excitatory after-effects over the primary motor cortex (M1). Recently, transcranial alternating current stimulation (tACS) at 10 Hz (α) and 20 Hz (β) have been shown to modulate M1 excitability in a phase-dependent manner. Therefore, we hypothesized that tACS would modulate the after-effects of iTBS depending on the stimulation frequency and phase. To test our hypothesis, we examined the effects of α- and β-tACS on iTBS using motor evoked potentials (MEPs). Eighteen and thirteen healthy participants were recruited for α and β tACS conditions, respectively. tACS electrodes were attached over the left M1 and Pz. iTBS over left M1 was performed concurrently with tACS. The first pulse of the triple-pulse burst of iTBS was controlled to match the peak (90°) or trough (270°) phase of the tACS. A sham tACS condition was used as a control in which iTBS was administered without tACS. Thus, each participant was tested in three conditions: the peak and trough of the tACS phases and sham tACS. As a result, MEPs were enhanced after iTBS without tACS (sham condition), as observed in previous studies. α-tACS suppressed iTBS effects at the peak phase but not at the trough phase, while β-tACS suppressed the effects at both phases. Thus, although both types of tACS inhibited the facilitatory effects of iTBS, only α-tACS did so in a phase-dependent manner. Phase-dependent inhibition by α-tACS is analogous to our previous finding in which α-tACS inhibited MEPs online at the peak condition. Conversely, β-tACS reduced the effects of iTBS irrespective of its phase. The coupling of brain oscillations and tACS rhythms is considered important in the generation of spike-timing-dependent plasticity. Additionally, the coupling of θ and γ oscillations is assumed to be important for iTBS induction through long-term potentiation (LTP). Therefore, excessive coupling between β oscillations induced by tACS and γ or θ oscillations induced by iTBS might disturb the coupling of θ and γ oscillations during iTBS. To conclude, the action of iTBS is differentially modulated by neuronal oscillations depending on whether α- or β-tACS is applied.
format	article
author	Katsuya Ogata Hisato Nakazono Takuro Ikeda Shin-ichiro Oka Yoshinobu Goto Shozo Tobimatsu
author_facet	Katsuya Ogata Hisato Nakazono Takuro Ikeda Shin-ichiro Oka Yoshinobu Goto Shozo Tobimatsu
author_sort	Katsuya Ogata
title	After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation
title_short	After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation
title_full	After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation
title_fullStr	After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation
title_full_unstemmed	After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation
title_sort	after-effects of intermittent theta-burst stimulation are differentially and phase-dependently suppressed by α- and β-frequency transcranial alternating current stimulation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/435859eead044441a986838e2e9d5ba5
work_keys_str_mv	AT katsuyaogata aftereffectsofintermittentthetaburststimulationaredifferentiallyandphasedependentlysuppressedbyaandbfrequencytranscranialalternatingcurrentstimulation AT hisatonakazono aftereffectsofintermittentthetaburststimulationaredifferentiallyandphasedependentlysuppressedbyaandbfrequencytranscranialalternatingcurrentstimulation AT takuroikeda aftereffectsofintermittentthetaburststimulationaredifferentiallyandphasedependentlysuppressedbyaandbfrequencytranscranialalternatingcurrentstimulation AT shinichirooka aftereffectsofintermittentthetaburststimulationaredifferentiallyandphasedependentlysuppressedbyaandbfrequencytranscranialalternatingcurrentstimulation AT yoshinobugoto aftereffectsofintermittentthetaburststimulationaredifferentiallyandphasedependentlysuppressedbyaandbfrequencytranscranialalternatingcurrentstimulation AT shozotobimatsu aftereffectsofintermittentthetaburststimulationaredifferentiallyandphasedependentlysuppressedbyaandbfrequencytranscranialalternatingcurrentstimulation
_version_	1718431164647079936

After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation

Ejemplares similares