Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.
<h4>Background</h4>Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions wi...
Saved in:
Main Authors: | Marie S Hasemann, Mikkel B Schuster, Anne-Katrine Frank, Kim Theilgaard-Mönch, Thomas Å Pedersen, Claus Nerlov, Bo T Porse |
---|---|
Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2012
|
Subjects: | |
Online Access: | https://doaj.org/article/435adf3ec52b4d42a64f1396f579cd8c |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner.
by: Ida Christine Norrie, et al.
Published: (2014) -
Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
by: Eric Chang-Yi Lin, et al.
Published: (2021) -
Identifying microRNA determinants of human myelopoiesis
by: Megha Rajasekhar, et al.
Published: (2018) -
CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1
by: You Jiang, et al.
Published: (2021) -
Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications.
by: Bilyana Stoilova, et al.
Published: (2013)