Cortical astrocytes develop in a plastic manner at both clonal and cellular levels

Previous studies on astrocyte development have led to controversial results due to a lack of pertinent tools. Here, authors analyze large numbers of astrocyte clones generated by nearby cortical progenitors using the MAGIC Markers strategy and ChroMS 3D imaging, and show that clonally-related astroc...

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Autores principales: Solène Clavreul, Lamiae Abdeladim, Edwin Hernández-Garzón, Dragos Niculescu, Jason Durand, Sio-Hoï Ieng, Raphaëlle Barry, Gilles Bonvento, Emmanuel Beaurepaire, Jean Livet, Karine Loulier
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/435d94e6bca044b89496f3445b4f4c83
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spelling oai:doaj.org-article:435d94e6bca044b89496f3445b4f4c832021-12-02T17:02:11ZCortical astrocytes develop in a plastic manner at both clonal and cellular levels10.1038/s41467-019-12791-52041-1723https://doaj.org/article/435d94e6bca044b89496f3445b4f4c832019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12791-5https://doaj.org/toc/2041-1723Previous studies on astrocyte development have led to controversial results due to a lack of pertinent tools. Here, authors analyze large numbers of astrocyte clones generated by nearby cortical progenitors using the MAGIC Markers strategy and ChroMS 3D imaging, and show that clonally-related astrocytes organize in a non-stereotyped manner and that cortical astrocyte subtypes are not intrinsically specified.Solène ClavreulLamiae AbdeladimEdwin Hernández-GarzónDragos NiculescuJason DurandSio-Hoï IengRaphaëlle BarryGilles BonventoEmmanuel BeaurepaireJean LivetKarine LoulierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Solène Clavreul
Lamiae Abdeladim
Edwin Hernández-Garzón
Dragos Niculescu
Jason Durand
Sio-Hoï Ieng
Raphaëlle Barry
Gilles Bonvento
Emmanuel Beaurepaire
Jean Livet
Karine Loulier
Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
description Previous studies on astrocyte development have led to controversial results due to a lack of pertinent tools. Here, authors analyze large numbers of astrocyte clones generated by nearby cortical progenitors using the MAGIC Markers strategy and ChroMS 3D imaging, and show that clonally-related astrocytes organize in a non-stereotyped manner and that cortical astrocyte subtypes are not intrinsically specified.
format article
author Solène Clavreul
Lamiae Abdeladim
Edwin Hernández-Garzón
Dragos Niculescu
Jason Durand
Sio-Hoï Ieng
Raphaëlle Barry
Gilles Bonvento
Emmanuel Beaurepaire
Jean Livet
Karine Loulier
author_facet Solène Clavreul
Lamiae Abdeladim
Edwin Hernández-Garzón
Dragos Niculescu
Jason Durand
Sio-Hoï Ieng
Raphaëlle Barry
Gilles Bonvento
Emmanuel Beaurepaire
Jean Livet
Karine Loulier
author_sort Solène Clavreul
title Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
title_short Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
title_full Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
title_fullStr Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
title_full_unstemmed Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
title_sort cortical astrocytes develop in a plastic manner at both clonal and cellular levels
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/435d94e6bca044b89496f3445b4f4c83
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AT edwinhernandezgarzon corticalastrocytesdevelopinaplasticmanneratbothclonalandcellularlevels
AT dragosniculescu corticalastrocytesdevelopinaplasticmanneratbothclonalandcellularlevels
AT jasondurand corticalastrocytesdevelopinaplasticmanneratbothclonalandcellularlevels
AT siohoiieng corticalastrocytesdevelopinaplasticmanneratbothclonalandcellularlevels
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AT karineloulier corticalastrocytesdevelopinaplasticmanneratbothclonalandcellularlevels
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