Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors

The bacterial effector MavC can ubiquitinate the host E2 enzyme UBE2N to dampen the host immune response. Here, the authors provide mechanistic insight into this non-canonical ubiquitination machinery and reveal the structural basis for the functional differences between MavC and its close homolog M...

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Autores principales:	Yong Wang, Qi Zhan, Xinlu Wang, Peipei Li, Songqing Liu, Guangxia Gao, Pu Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/435e48a96c5f4025b607ca9f58b330df
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spelling	oai:doaj.org-article:435e48a96c5f4025b607ca9f58b330df2021-12-02T15:02:55ZInsights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors10.1038/s41467-020-16587-w2041-1723https://doaj.org/article/435e48a96c5f4025b607ca9f58b330df2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16587-whttps://doaj.org/toc/2041-1723The bacterial effector MavC can ubiquitinate the host E2 enzyme UBE2N to dampen the host immune response. Here, the authors provide mechanistic insight into this non-canonical ubiquitination machinery and reveal the structural basis for the functional differences between MavC and its close homolog MvcA.Yong WangQi ZhanXinlu WangPeipei LiSongqing LiuGuangxia GaoPu GaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong Wang Qi Zhan Xinlu Wang Peipei Li Songqing Liu Guangxia Gao Pu Gao Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
description	The bacterial effector MavC can ubiquitinate the host E2 enzyme UBE2N to dampen the host immune response. Here, the authors provide mechanistic insight into this non-canonical ubiquitination machinery and reveal the structural basis for the functional differences between MavC and its close homolog MvcA.
format	article
author	Yong Wang Qi Zhan Xinlu Wang Peipei Li Songqing Liu Guangxia Gao Pu Gao
author_facet	Yong Wang Qi Zhan Xinlu Wang Peipei Li Songqing Liu Guangxia Gao Pu Gao
author_sort	Yong Wang
title	Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
title_short	Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
title_full	Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
title_fullStr	Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
title_full_unstemmed	Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
title_sort	insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/435e48a96c5f4025b607ca9f58b330df
work_keys_str_mv	AT yongwang insightsintocatalysisandregulationofnoncanonicalubiquitinationanddeubiquitinationbybacterialdeamidaseeffectors AT qizhan insightsintocatalysisandregulationofnoncanonicalubiquitinationanddeubiquitinationbybacterialdeamidaseeffectors AT xinluwang insightsintocatalysisandregulationofnoncanonicalubiquitinationanddeubiquitinationbybacterialdeamidaseeffectors AT peipeili insightsintocatalysisandregulationofnoncanonicalubiquitinationanddeubiquitinationbybacterialdeamidaseeffectors AT songqingliu insightsintocatalysisandregulationofnoncanonicalubiquitinationanddeubiquitinationbybacterialdeamidaseeffectors AT guangxiagao insightsintocatalysisandregulationofnoncanonicalubiquitinationanddeubiquitinationbybacterialdeamidaseeffectors AT pugao insightsintocatalysisandregulationofnoncanonicalubiquitinationanddeubiquitinationbybacterialdeamidaseeffectors
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Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors

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