Understanding CRY2 interactions for optical control of intracellular signaling

Cryptochrome 2 (CRY2) can form light-regulated CRY2-CRY2 homo-oligomers or CRY2-CIB1 hetero-dimers, but modulating these interactions is difficult owing to the lack of interaction mechanism. Here the authors identify the interactions facilitating homo-oligomers and introduce mutations to create low...

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Autores principales:	Liting Duan, Jen Hope, Qunxiang Ong, Hsin-Ya Lou, Namdoo Kim, Comfrey McCarthy, Victor Acero, Michael Z. Lin, Bianxiao Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/435e73dda8cb424e8a0087f173f65aa4
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spelling	oai:doaj.org-article:435e73dda8cb424e8a0087f173f65aa42021-12-02T17:06:30ZUnderstanding CRY2 interactions for optical control of intracellular signaling10.1038/s41467-017-00648-82041-1723https://doaj.org/article/435e73dda8cb424e8a0087f173f65aa42017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00648-8https://doaj.org/toc/2041-1723Cryptochrome 2 (CRY2) can form light-regulated CRY2-CRY2 homo-oligomers or CRY2-CIB1 hetero-dimers, but modulating these interactions is difficult owing to the lack of interaction mechanism. Here the authors identify the interactions facilitating homo-oligomers and introduce mutations to create low and high oligomerization versions.Liting DuanJen HopeQunxiang OngHsin-Ya LouNamdoo KimComfrey McCarthyVictor AceroMichael Z. LinBianxiao CuiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liting Duan Jen Hope Qunxiang Ong Hsin-Ya Lou Namdoo Kim Comfrey McCarthy Victor Acero Michael Z. Lin Bianxiao Cui Understanding CRY2 interactions for optical control of intracellular signaling
description	Cryptochrome 2 (CRY2) can form light-regulated CRY2-CRY2 homo-oligomers or CRY2-CIB1 hetero-dimers, but modulating these interactions is difficult owing to the lack of interaction mechanism. Here the authors identify the interactions facilitating homo-oligomers and introduce mutations to create low and high oligomerization versions.
format	article
author	Liting Duan Jen Hope Qunxiang Ong Hsin-Ya Lou Namdoo Kim Comfrey McCarthy Victor Acero Michael Z. Lin Bianxiao Cui
author_facet	Liting Duan Jen Hope Qunxiang Ong Hsin-Ya Lou Namdoo Kim Comfrey McCarthy Victor Acero Michael Z. Lin Bianxiao Cui
author_sort	Liting Duan
title	Understanding CRY2 interactions for optical control of intracellular signaling
title_short	Understanding CRY2 interactions for optical control of intracellular signaling
title_full	Understanding CRY2 interactions for optical control of intracellular signaling
title_fullStr	Understanding CRY2 interactions for optical control of intracellular signaling
title_full_unstemmed	Understanding CRY2 interactions for optical control of intracellular signaling
title_sort	understanding cry2 interactions for optical control of intracellular signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/435e73dda8cb424e8a0087f173f65aa4
work_keys_str_mv	AT litingduan understandingcry2interactionsforopticalcontrolofintracellularsignaling AT jenhope understandingcry2interactionsforopticalcontrolofintracellularsignaling AT qunxiangong understandingcry2interactionsforopticalcontrolofintracellularsignaling AT hsinyalou understandingcry2interactionsforopticalcontrolofintracellularsignaling AT namdookim understandingcry2interactionsforopticalcontrolofintracellularsignaling AT comfreymccarthy understandingcry2interactionsforopticalcontrolofintracellularsignaling AT victoracero understandingcry2interactionsforopticalcontrolofintracellularsignaling AT michaelzlin understandingcry2interactionsforopticalcontrolofintracellularsignaling AT bianxiaocui understandingcry2interactionsforopticalcontrolofintracellularsignaling
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Understanding CRY2 interactions for optical control of intracellular signaling

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