The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle

Abstract The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and surgical specimens from patients with int...

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Autores principales:	Gail Ishiyama, Ivan A. Lopez, Paul Ishiyama, Harry V. Vinters, Akira Ishiyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/435ef493d41f4a86a82a5fc5e5888073
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spelling	oai:doaj.org-article:435ef493d41f4a86a82a5fc5e58880732021-12-02T12:32:08ZThe blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle10.1038/s41598-017-00330-52045-2322https://doaj.org/article/435ef493d41f4a86a82a5fc5e58880732017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00330-5https://doaj.org/toc/2045-2322Abstract The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and surgical specimens from patients with intractable Meniere’s disease. Transmission electron microscopic analysis of capillaries located in the normal human utricular stroma showed vascular endothelial cells with few pinocytotic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes. Meniere’s disease specimens revealed differential ultrastructural pathological changes in the cellular elements of the microvasculature. With moderate degeneration of the BLB, there were numerous vesicles within the vascular endothelial cells (VECs), with increased numbers at the abluminal face, pericyte process detachment and disruption of the perivascular basement membrane surrounding the VECs. With severe degeneration of the BLB, there was severe vacuolization or frank apparent necrosis of VECs and loss of subcellular organelles. A higher severity of BLB degenerative changes was associated with a higher degree of basement membrane thickening and edematous changes within the vestibular stroma. This study presents the first ultrastructural analysis of the capillaries constituting the BLB in the human vestibular macula utricle from normal and Meniere’s disease.Gail IshiyamaIvan A. LopezPaul IshiyamaHarry V. VintersAkira IshiyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gail Ishiyama Ivan A. Lopez Paul Ishiyama Harry V. Vinters Akira Ishiyama The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
description	Abstract The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and surgical specimens from patients with intractable Meniere’s disease. Transmission electron microscopic analysis of capillaries located in the normal human utricular stroma showed vascular endothelial cells with few pinocytotic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes. Meniere’s disease specimens revealed differential ultrastructural pathological changes in the cellular elements of the microvasculature. With moderate degeneration of the BLB, there were numerous vesicles within the vascular endothelial cells (VECs), with increased numbers at the abluminal face, pericyte process detachment and disruption of the perivascular basement membrane surrounding the VECs. With severe degeneration of the BLB, there was severe vacuolization or frank apparent necrosis of VECs and loss of subcellular organelles. A higher severity of BLB degenerative changes was associated with a higher degree of basement membrane thickening and edematous changes within the vestibular stroma. This study presents the first ultrastructural analysis of the capillaries constituting the BLB in the human vestibular macula utricle from normal and Meniere’s disease.
format	article
author	Gail Ishiyama Ivan A. Lopez Paul Ishiyama Harry V. Vinters Akira Ishiyama
author_facet	Gail Ishiyama Ivan A. Lopez Paul Ishiyama Harry V. Vinters Akira Ishiyama
author_sort	Gail Ishiyama
title	The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
title_short	The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
title_full	The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
title_fullStr	The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
title_full_unstemmed	The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
title_sort	blood labyrinthine barrier in the human normal and meniere’s disease macula utricle
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/435ef493d41f4a86a82a5fc5e5888073
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The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle

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