MORC protein family-related signature within human disease and cancer

Abstract The microrchidia (MORC) family of proteins is a highly conserved nuclear protein superfamily, whose members contain common domain structures (GHKL-ATPase, CW-type zinc finger and coiled-coil domain) yet exhibit diverse biological functions. Despite the advancing research in previous decades...

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Autores principales:	Huan Wang, Ling Zhang, Qiuhua Luo, Jia Liu, Guiling Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/4360687f350f447ab33f7b556dc13e97
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spelling	oai:doaj.org-article:4360687f350f447ab33f7b556dc13e972021-11-28T12:04:18ZMORC protein family-related signature within human disease and cancer10.1038/s41419-021-04393-12041-4889https://doaj.org/article/4360687f350f447ab33f7b556dc13e972021-11-01T00:00:00Zhttps://doi.org/10.1038/s41419-021-04393-1https://doaj.org/toc/2041-4889Abstract The microrchidia (MORC) family of proteins is a highly conserved nuclear protein superfamily, whose members contain common domain structures (GHKL-ATPase, CW-type zinc finger and coiled-coil domain) yet exhibit diverse biological functions. Despite the advancing research in previous decades, much of which focuses on their role as epigenetic regulators and in chromatin remodeling, relatively little is known about the role of MORCs in tumorigenesis and pathogenesis. MORCs were first identified as epigenetic regulators and chromatin remodelers in germ cell development. Currently, MORCs are regarded as disease genes that are involved in various human disorders and oncogenes in cancer progression and are expected to be the important biomarkers for diagnosis and treatment. A new paradigm of expanded MORC family function has raised questions regarding the regulation of MORCs and their biological role at the subcellular level. Here, we systematically review the progress of researching MORC members with respect to their domain architectures, diverse biological functions, and distribution characteristics and discuss the emerging roles of the aberrant expression or mutation of MORC family members in human disorders and cancer development. Furthermore, the illustration of related mechanisms of the MORC family has made MORCs promising targets for developing diagnostic tools and therapeutic treatments for human diseases, including cancers.Huan WangLing ZhangQiuhua LuoJia LiuGuiling WangNature Publishing GrouparticleCytologyQH573-671ENCell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Huan Wang Ling Zhang Qiuhua Luo Jia Liu Guiling Wang MORC protein family-related signature within human disease and cancer
description	Abstract The microrchidia (MORC) family of proteins is a highly conserved nuclear protein superfamily, whose members contain common domain structures (GHKL-ATPase, CW-type zinc finger and coiled-coil domain) yet exhibit diverse biological functions. Despite the advancing research in previous decades, much of which focuses on their role as epigenetic regulators and in chromatin remodeling, relatively little is known about the role of MORCs in tumorigenesis and pathogenesis. MORCs were first identified as epigenetic regulators and chromatin remodelers in germ cell development. Currently, MORCs are regarded as disease genes that are involved in various human disorders and oncogenes in cancer progression and are expected to be the important biomarkers for diagnosis and treatment. A new paradigm of expanded MORC family function has raised questions regarding the regulation of MORCs and their biological role at the subcellular level. Here, we systematically review the progress of researching MORC members with respect to their domain architectures, diverse biological functions, and distribution characteristics and discuss the emerging roles of the aberrant expression or mutation of MORC family members in human disorders and cancer development. Furthermore, the illustration of related mechanisms of the MORC family has made MORCs promising targets for developing diagnostic tools and therapeutic treatments for human diseases, including cancers.
format	article
author	Huan Wang Ling Zhang Qiuhua Luo Jia Liu Guiling Wang
author_facet	Huan Wang Ling Zhang Qiuhua Luo Jia Liu Guiling Wang
author_sort	Huan Wang
title	MORC protein family-related signature within human disease and cancer
title_short	MORC protein family-related signature within human disease and cancer
title_full	MORC protein family-related signature within human disease and cancer
title_fullStr	MORC protein family-related signature within human disease and cancer
title_full_unstemmed	MORC protein family-related signature within human disease and cancer
title_sort	morc protein family-related signature within human disease and cancer
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/4360687f350f447ab33f7b556dc13e97
work_keys_str_mv	AT huanwang morcproteinfamilyrelatedsignaturewithinhumandiseaseandcancer AT lingzhang morcproteinfamilyrelatedsignaturewithinhumandiseaseandcancer AT qiuhualuo morcproteinfamilyrelatedsignaturewithinhumandiseaseandcancer AT jialiu morcproteinfamilyrelatedsignaturewithinhumandiseaseandcancer AT guilingwang morcproteinfamilyrelatedsignaturewithinhumandiseaseandcancer
_version_	1718408193509425152

MORC protein family-related signature within human disease and cancer

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