A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA

Objective: To compare the efficacy of Intradermal Tranexamic acid and topical 20% Azelaic acid cream in the treatment of melasma. Study Design: Comparative prospective study. Place and Duration of Study: Dermatology department, Combined Military Hospital Peshawar, from Sep 2018 to Mar 2019....

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Autores principales:	Sayyida Komal, Asher Ahmed Mashhood, Muhammad Farooq, Nida Qayyum
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	azelaic acid intradermal injections melasma topical therapy tranexamic acid Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/436193d9e36e4fa3aa121f2d0605eb40
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spelling	oai:doaj.org-article:436193d9e36e4fa3aa121f2d0605eb402021-12-02T18:01:39ZA COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA0030-96482411-884210.51253/pafmj.v71i2.4528https://doaj.org/article/436193d9e36e4fa3aa121f2d0605eb402021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/4528https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare the efficacy of Intradermal Tranexamic acid and topical 20% Azelaic acid cream in the treatment of melasma. Study Design: Comparative prospective study. Place and Duration of Study: Dermatology department, Combined Military Hospital Peshawar, from Sep 2018 to Mar 2019. Methodology: A total of 116 female patients, at the outpatient department of dermatology at Combined Military Hospital Peshawar, were randomly assigned into two groups; group A (intradermal tranexamic acid) and group B (topical azelaic acid) by lottery method. Patients in group A received intradermal injection, while the participants of group B received topical azelaic acid only, fortnightly for 6 weeks. Melasma area severity index score was calculated for each patient in both groups at the start and at the end of the treatment. Results: The mean Melasma area severity index score in group A (intradermal tranexamic acid) before and at 6 weeks of treatment was 7.10 ± 2.94 and 5.27 ± 2.44, respectively. The mean Melasma area severity index score in group B (topical azelaic acid) before and at 6 weeks of treatment was 7.56 ± 2.57 and 5.76 ± 2.89, respectively. Efficacy of intradermal tranexamic acid, as poor response, good response and excellent response was 27.6%, 41.4% and 31% respectively. While, efficacy of topical azelaic acid group as poor response, good response and excellent response was 62.1%, 20.7% and 17.2% respectively. The difference was statistically significant, (p=0.001). Conclusion: It can be concluded that intradermal tranexamic acid is more effective as compared to topical 20% azelaic acid in..................Sayyida KomalAsher Ahmed MashhoodMuhammad FarooqNida QayyumArmy Medical College Rawalpindiarticleazelaic acidintradermal injectionsmelasmatopical therapytranexamic acidMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 494-97 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	azelaic acid intradermal injections melasma topical therapy tranexamic acid Medicine R Medicine (General) R5-920
spellingShingle	azelaic acid intradermal injections melasma topical therapy tranexamic acid Medicine R Medicine (General) R5-920 Sayyida Komal Asher Ahmed Mashhood Muhammad Farooq Nida Qayyum A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA
description	Objective: To compare the efficacy of Intradermal Tranexamic acid and topical 20% Azelaic acid cream in the treatment of melasma. Study Design: Comparative prospective study. Place and Duration of Study: Dermatology department, Combined Military Hospital Peshawar, from Sep 2018 to Mar 2019. Methodology: A total of 116 female patients, at the outpatient department of dermatology at Combined Military Hospital Peshawar, were randomly assigned into two groups; group A (intradermal tranexamic acid) and group B (topical azelaic acid) by lottery method. Patients in group A received intradermal injection, while the participants of group B received topical azelaic acid only, fortnightly for 6 weeks. Melasma area severity index score was calculated for each patient in both groups at the start and at the end of the treatment. Results: The mean Melasma area severity index score in group A (intradermal tranexamic acid) before and at 6 weeks of treatment was 7.10 ± 2.94 and 5.27 ± 2.44, respectively. The mean Melasma area severity index score in group B (topical azelaic acid) before and at 6 weeks of treatment was 7.56 ± 2.57 and 5.76 ± 2.89, respectively. Efficacy of intradermal tranexamic acid, as poor response, good response and excellent response was 27.6%, 41.4% and 31% respectively. While, efficacy of topical azelaic acid group as poor response, good response and excellent response was 62.1%, 20.7% and 17.2% respectively. The difference was statistically significant, (p=0.001). Conclusion: It can be concluded that intradermal tranexamic acid is more effective as compared to topical 20% azelaic acid in..................
format	article
author	Sayyida Komal Asher Ahmed Mashhood Muhammad Farooq Nida Qayyum
author_facet	Sayyida Komal Asher Ahmed Mashhood Muhammad Farooq Nida Qayyum
author_sort	Sayyida Komal
title	A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA
title_short	A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA
title_full	A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA
title_fullStr	A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA
title_full_unstemmed	A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA
title_sort	comparison of efficacy of intradermal tranexamic acid with topical 20% azelaic acid in the treatment of melasma
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/436193d9e36e4fa3aa121f2d0605eb40
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A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA

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