The integration of prosodic speech in high functioning autism: a preliminary FMRI study.

<h4>Background</h4>Autism is a neurodevelopmental disorder characterized by a specific triad of symptoms such as abnormalities in social interaction, abnormalities in communication and restricted activities and interests. While verbal autistic subjects may present a correct mastery of th...

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Autores principales:	Isabelle Hesling, Bixente Dilharreguy, Sue Peppé, Marion Amirault, Manuel Bouvard, Michèle Allard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4361af34437843cfa351f403e4c372e5
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spelling	oai:doaj.org-article:4361af34437843cfa351f403e4c372e52021-12-02T20:20:07ZThe integration of prosodic speech in high functioning autism: a preliminary FMRI study.1932-620310.1371/journal.pone.0011571https://doaj.org/article/4361af34437843cfa351f403e4c372e52010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20644633/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Autism is a neurodevelopmental disorder characterized by a specific triad of symptoms such as abnormalities in social interaction, abnormalities in communication and restricted activities and interests. While verbal autistic subjects may present a correct mastery of the formal aspects of speech, they have difficulties in prosody (music of speech), leading to communication disorders. Few behavioural studies have revealed a prosodic impairment in children with autism, and among the few fMRI studies aiming at assessing the neural network involved in language, none has specifically studied prosodic speech. The aim of the present study was to characterize specific prosodic components such as linguistic prosody (intonation, rhythm and emphasis) and emotional prosody and to correlate them with the neural network underlying them.<h4>Methodology/principal findings</h4>We used a behavioural test (Profiling Elements of the Prosodic System, PEPS) and fMRI to characterize prosodic deficits and investigate the neural network underlying prosodic processing. Results revealed the existence of a link between perceptive and productive prosodic deficits for some prosodic components (rhythm, emphasis and affect) in HFA and also revealed that the neural network involved in prosodic speech perception exhibits abnormal activation in the left SMG as compared to controls (activation positively correlated with intonation and emphasis) and an absence of deactivation patterns in regions involved in the default mode.<h4>Conclusions/significance</h4>These prosodic impairments could not only result from activation patterns abnormalities but also from an inability to adequately use the strategy of the default network inhibition, both mechanisms that have to be considered for decreasing task performance in High Functioning Autism.Isabelle HeslingBixente DilharreguySue PeppéMarion AmiraultManuel BouvardMichèle AllardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 7, p e11571 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabelle Hesling Bixente Dilharreguy Sue Peppé Marion Amirault Manuel Bouvard Michèle Allard The integration of prosodic speech in high functioning autism: a preliminary FMRI study.
description	<h4>Background</h4>Autism is a neurodevelopmental disorder characterized by a specific triad of symptoms such as abnormalities in social interaction, abnormalities in communication and restricted activities and interests. While verbal autistic subjects may present a correct mastery of the formal aspects of speech, they have difficulties in prosody (music of speech), leading to communication disorders. Few behavioural studies have revealed a prosodic impairment in children with autism, and among the few fMRI studies aiming at assessing the neural network involved in language, none has specifically studied prosodic speech. The aim of the present study was to characterize specific prosodic components such as linguistic prosody (intonation, rhythm and emphasis) and emotional prosody and to correlate them with the neural network underlying them.<h4>Methodology/principal findings</h4>We used a behavioural test (Profiling Elements of the Prosodic System, PEPS) and fMRI to characterize prosodic deficits and investigate the neural network underlying prosodic processing. Results revealed the existence of a link between perceptive and productive prosodic deficits for some prosodic components (rhythm, emphasis and affect) in HFA and also revealed that the neural network involved in prosodic speech perception exhibits abnormal activation in the left SMG as compared to controls (activation positively correlated with intonation and emphasis) and an absence of deactivation patterns in regions involved in the default mode.<h4>Conclusions/significance</h4>These prosodic impairments could not only result from activation patterns abnormalities but also from an inability to adequately use the strategy of the default network inhibition, both mechanisms that have to be considered for decreasing task performance in High Functioning Autism.
format	article
author	Isabelle Hesling Bixente Dilharreguy Sue Peppé Marion Amirault Manuel Bouvard Michèle Allard
author_facet	Isabelle Hesling Bixente Dilharreguy Sue Peppé Marion Amirault Manuel Bouvard Michèle Allard
author_sort	Isabelle Hesling
title	The integration of prosodic speech in high functioning autism: a preliminary FMRI study.
title_short	The integration of prosodic speech in high functioning autism: a preliminary FMRI study.
title_full	The integration of prosodic speech in high functioning autism: a preliminary FMRI study.
title_fullStr	The integration of prosodic speech in high functioning autism: a preliminary FMRI study.
title_full_unstemmed	The integration of prosodic speech in high functioning autism: a preliminary FMRI study.
title_sort	integration of prosodic speech in high functioning autism: a preliminary fmri study.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/4361af34437843cfa351f403e4c372e5
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The integration of prosodic speech in high functioning autism: a preliminary FMRI study.

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