The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia
LncRNAs at the HOX gene locus are increased in expression in NPM1 mutant acute myeloid leukemia. In this study, the authors show that one such lncRNA, HOX3B-AS3, has a role in regulating gene transcription and protein synthesis in leukemia cells.
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Nature Portfolio
2019
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oai:doaj.org-article:4362506e0cc14ab88f90e66fd4195bb22021-12-02T17:01:27ZThe long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia10.1038/s41467-019-13259-22041-1723https://doaj.org/article/4362506e0cc14ab88f90e66fd4195bb22019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13259-2https://doaj.org/toc/2041-1723LncRNAs at the HOX gene locus are increased in expression in NPM1 mutant acute myeloid leukemia. In this study, the authors show that one such lncRNA, HOX3B-AS3, has a role in regulating gene transcription and protein synthesis in leukemia cells.Dimitrios PapaioannouAndreas PetriOliver M. DoveySara TerreriEric WangFrances A. CollinsLauren A. WoodwardAllison E. WalkerDeedra NicoletFelice PepePrasanthi KumchalaMarius BillChristopher J. WalkerMalith KarunasiriKrzysztof MrózekMiranda L. GardnerVirginia CamilottoNina ZitzerJonathan L. CooperXiongwei CaiXiaoqing Rong-MullinsJessica KohlschmidtKellie J. ArcherMichael A. FreitasYi ZhengRobert J. LeeIannis AifantisGeorge VassiliouGuramrit SinghSakari KauppinenClara D. BloomfieldAdrienne M. DorranceRamiro GarzonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
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EN |
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Science Q |
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Science Q Dimitrios Papaioannou Andreas Petri Oliver M. Dovey Sara Terreri Eric Wang Frances A. Collins Lauren A. Woodward Allison E. Walker Deedra Nicolet Felice Pepe Prasanthi Kumchala Marius Bill Christopher J. Walker Malith Karunasiri Krzysztof Mrózek Miranda L. Gardner Virginia Camilotto Nina Zitzer Jonathan L. Cooper Xiongwei Cai Xiaoqing Rong-Mullins Jessica Kohlschmidt Kellie J. Archer Michael A. Freitas Yi Zheng Robert J. Lee Iannis Aifantis George Vassiliou Guramrit Singh Sakari Kauppinen Clara D. Bloomfield Adrienne M. Dorrance Ramiro Garzon The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia |
| description |
LncRNAs at the HOX gene locus are increased in expression in NPM1 mutant acute myeloid leukemia. In this study, the authors show that one such lncRNA, HOX3B-AS3, has a role in regulating gene transcription and protein synthesis in leukemia cells. |
| format |
article |
| author |
Dimitrios Papaioannou Andreas Petri Oliver M. Dovey Sara Terreri Eric Wang Frances A. Collins Lauren A. Woodward Allison E. Walker Deedra Nicolet Felice Pepe Prasanthi Kumchala Marius Bill Christopher J. Walker Malith Karunasiri Krzysztof Mrózek Miranda L. Gardner Virginia Camilotto Nina Zitzer Jonathan L. Cooper Xiongwei Cai Xiaoqing Rong-Mullins Jessica Kohlschmidt Kellie J. Archer Michael A. Freitas Yi Zheng Robert J. Lee Iannis Aifantis George Vassiliou Guramrit Singh Sakari Kauppinen Clara D. Bloomfield Adrienne M. Dorrance Ramiro Garzon |
| author_facet |
Dimitrios Papaioannou Andreas Petri Oliver M. Dovey Sara Terreri Eric Wang Frances A. Collins Lauren A. Woodward Allison E. Walker Deedra Nicolet Felice Pepe Prasanthi Kumchala Marius Bill Christopher J. Walker Malith Karunasiri Krzysztof Mrózek Miranda L. Gardner Virginia Camilotto Nina Zitzer Jonathan L. Cooper Xiongwei Cai Xiaoqing Rong-Mullins Jessica Kohlschmidt Kellie J. Archer Michael A. Freitas Yi Zheng Robert J. Lee Iannis Aifantis George Vassiliou Guramrit Singh Sakari Kauppinen Clara D. Bloomfield Adrienne M. Dorrance Ramiro Garzon |
| author_sort |
Dimitrios Papaioannou |
| title |
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia |
| title_short |
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia |
| title_full |
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia |
| title_fullStr |
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia |
| title_full_unstemmed |
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia |
| title_sort |
long non-coding rna hoxb-as3 regulates ribosomal rna transcription in npm1-mutated acute myeloid leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4362506e0cc14ab88f90e66fd4195bb2 |
| work_keys_str_mv |
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