Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system

Purpose The ExAblate body MRgFUS system requires advanced beamforming strategies for volumetric hyperthermia. This study aims to develop and evaluate electronic beam steering, multi-focal patterns, and sector vortex beamforming approaches in conjunction with partial array activation using an acousti...

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Autores principales:	Kisoo Kim, Muhammad Zubair, Matthew Adams, Chris J. Diederich, Eugene Ozhinsky
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	hyperthermia high intensity focused ultrasound mr thermometry mrgfus exablate body array Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/4362839efee846238bf29a7f0e02fbe7
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spelling	oai:doaj.org-article:4362839efee846238bf29a7f0e02fbe72021-11-11T14:23:40ZSonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system0265-67361464-515710.1080/02656736.2021.1998658https://doaj.org/article/4362839efee846238bf29a7f0e02fbe72021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/02656736.2021.1998658https://doaj.org/toc/0265-6736https://doaj.org/toc/1464-5157Purpose The ExAblate body MRgFUS system requires advanced beamforming strategies for volumetric hyperthermia. This study aims to develop and evaluate electronic beam steering, multi-focal patterns, and sector vortex beamforming approaches in conjunction with partial array activation using an acoustic and biothermal simulation framework along with phantom experiments. Methods The simulation framework was developed to calculate the 3D acoustic intensity and temperature distribution resulting from various beamforming and scanning strategies. A treatment cell electronically sweeping a single focus was implemented and evaluated in phantom experiments. The acoustic and thermal focal size of vortex beam propagation was quantified according to the vortex modes, number of active array elements, and focal depth. Results Turning off a percentage of the outer array to increase the f-number increased the focal size with a decrease in focal gain. 60% active elements allowed generating a sonication cell with an off-axis of 10 mm. The vortex mode number 4 with 60% active elements resulted in a larger heating volume than using the full array. Volumetric hyperthermia in the phantom was evaluated with the vortex mode 4 and respectively performed with 100% and 80% active elements. MR thermometry demonstrated that the volumes were found to be 18.8 and 29.7 cm3, respectively, with 80% array activation producing 1.58 times larger volume than the full array. Conclusions This study demonstrated that both electronic beam steering and sector vortex beamforming approaches in conjunction with partial array activation could generate large volume heating for HT delivery using the ExAblate body array.Kisoo KimMuhammad ZubairMatthew AdamsChris J. DiederichEugene OzhinskyTaylor & Francis Grouparticlehyperthermiahigh intensity focused ultrasoundmr thermometrymrgfusexablate body arrayMedical technologyR855-855.5ENInternational Journal of Hyperthermia, Vol 38, Iss 1, Pp 1590-1600 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperthermia high intensity focused ultrasound mr thermometry mrgfus exablate body array Medical technology R855-855.5
spellingShingle	hyperthermia high intensity focused ultrasound mr thermometry mrgfus exablate body array Medical technology R855-855.5 Kisoo Kim Muhammad Zubair Matthew Adams Chris J. Diederich Eugene Ozhinsky Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system
description	Purpose The ExAblate body MRgFUS system requires advanced beamforming strategies for volumetric hyperthermia. This study aims to develop and evaluate electronic beam steering, multi-focal patterns, and sector vortex beamforming approaches in conjunction with partial array activation using an acoustic and biothermal simulation framework along with phantom experiments. Methods The simulation framework was developed to calculate the 3D acoustic intensity and temperature distribution resulting from various beamforming and scanning strategies. A treatment cell electronically sweeping a single focus was implemented and evaluated in phantom experiments. The acoustic and thermal focal size of vortex beam propagation was quantified according to the vortex modes, number of active array elements, and focal depth. Results Turning off a percentage of the outer array to increase the f-number increased the focal size with a decrease in focal gain. 60% active elements allowed generating a sonication cell with an off-axis of 10 mm. The vortex mode number 4 with 60% active elements resulted in a larger heating volume than using the full array. Volumetric hyperthermia in the phantom was evaluated with the vortex mode 4 and respectively performed with 100% and 80% active elements. MR thermometry demonstrated that the volumes were found to be 18.8 and 29.7 cm3, respectively, with 80% array activation producing 1.58 times larger volume than the full array. Conclusions This study demonstrated that both electronic beam steering and sector vortex beamforming approaches in conjunction with partial array activation could generate large volume heating for HT delivery using the ExAblate body array.
format	article
author	Kisoo Kim Muhammad Zubair Matthew Adams Chris J. Diederich Eugene Ozhinsky
author_facet	Kisoo Kim Muhammad Zubair Matthew Adams Chris J. Diederich Eugene Ozhinsky
author_sort	Kisoo Kim
title	Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system
title_short	Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system
title_full	Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system
title_fullStr	Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system
title_full_unstemmed	Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system
title_sort	sonication strategies toward volumetric ultrasound hyperthermia treatment using the exablate body mrgfus system
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/4362839efee846238bf29a7f0e02fbe7
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Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system

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