The role of TIM-containing molecules in airway disease and their potential as therapeutic targets

Isabel Vega-Carrascal, Emer P Reeves, Noel G McElvaneyRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandAbstract: T cell immunoglobulin and mucin-domain (TIM)-containing molecules have emerged...

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Autores principales:	Vega-Carrascal I, Reeves EP, McElvaney NG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/4362b91b3d4949fcbe762283a6c7f156
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spelling	oai:doaj.org-article:4362b91b3d4949fcbe762283a6c7f1562021-12-02T06:48:58ZThe role of TIM-containing molecules in airway disease and their potential as therapeutic targets1178-7031https://doaj.org/article/4362b91b3d4949fcbe762283a6c7f1562012-08-01T00:00:00Zhttp://www.dovepress.com/the-role-of-tim-containing-molecules-in-airway-disease-and-their-poten-a10688https://doaj.org/toc/1178-7031Isabel Vega-Carrascal, Emer P Reeves, Noel G McElvaneyRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandAbstract: T cell immunoglobulin and mucin-domain (TIM)-containing molecules have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. Despite the initial discovery linking TIM-containing molecules and the airway hyperreactivity regulatory locus in mice, there is a paucity of studies on the function of TIM-containing molecules in lung inflammatory disease. Initially, studies were limited to mice models of asthma. More recently however, TIM-containing molecules have been implicated in an ever-expanding list of airway conditions that includes pneumonia, tuberculosis, influenza, sarcoidosis, lung cancer, and cystic fibrosis. This present review discusses the role of TIM-containing molecules and their ligands in the lung, as well as their potential as therapeutic targets in airway disease.Keywords: T cell immunoglobulin and mucin-domain, inflammation, galectin-9, airway diseaseVega-Carrascal IReeves EPMcElvaney NGDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2012, Iss default, Pp 77-87 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Vega-Carrascal I Reeves EP McElvaney NG The role of TIM-containing molecules in airway disease and their potential as therapeutic targets
description	Isabel Vega-Carrascal, Emer P Reeves, Noel G McElvaneyRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandAbstract: T cell immunoglobulin and mucin-domain (TIM)-containing molecules have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. Despite the initial discovery linking TIM-containing molecules and the airway hyperreactivity regulatory locus in mice, there is a paucity of studies on the function of TIM-containing molecules in lung inflammatory disease. Initially, studies were limited to mice models of asthma. More recently however, TIM-containing molecules have been implicated in an ever-expanding list of airway conditions that includes pneumonia, tuberculosis, influenza, sarcoidosis, lung cancer, and cystic fibrosis. This present review discusses the role of TIM-containing molecules and their ligands in the lung, as well as their potential as therapeutic targets in airway disease.Keywords: T cell immunoglobulin and mucin-domain, inflammation, galectin-9, airway disease
format	article
author	Vega-Carrascal I Reeves EP McElvaney NG
author_facet	Vega-Carrascal I Reeves EP McElvaney NG
author_sort	Vega-Carrascal I
title	The role of TIM-containing molecules in airway disease and their potential as therapeutic targets
title_short	The role of TIM-containing molecules in airway disease and their potential as therapeutic targets
title_full	The role of TIM-containing molecules in airway disease and their potential as therapeutic targets
title_fullStr	The role of TIM-containing molecules in airway disease and their potential as therapeutic targets
title_full_unstemmed	The role of TIM-containing molecules in airway disease and their potential as therapeutic targets
title_sort	role of tim-containing molecules in airway disease and their potential as therapeutic targets
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/4362b91b3d4949fcbe762283a6c7f156
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The role of TIM-containing molecules in airway disease and their potential as therapeutic targets

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