Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage

Abstract Glaucoma is a multifactorial optic neuropathy, possibly involving vascular dysfunction, leading to the death of retinal ganglion cells and their axons. Disc hemorrhage (DH) is known to be closely associated with the widening of retinal nerve fiber layer defect (NFLD); however, it has not be...

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Autores principales:	Yoko Okamoto, Tadamichi Akagi, Kenji Suda, Takanori Kameda, Masahiro Miyake, Hanako Ohashi Ikeda, Eri Nakano, Akihito Uji, Akitaka Tsujikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43657031cb2b433b81e75e6f0f80fe9a
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spelling	oai:doaj.org-article:43657031cb2b433b81e75e6f0f80fe9a2021-12-02T12:42:27ZLongitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage10.1038/s41598-020-79151-y2045-2322https://doaj.org/article/43657031cb2b433b81e75e6f0f80fe9a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79151-yhttps://doaj.org/toc/2045-2322Abstract Glaucoma is a multifactorial optic neuropathy, possibly involving vascular dysfunction, leading to the death of retinal ganglion cells and their axons. Disc hemorrhage (DH) is known to be closely associated with the widening of retinal nerve fiber layer defect (NFLD); however, it has not been well elucidated how DH affects retinal microvasculature. We aimed to investigate the association between DH history and longitudinal changes in superficial retinal microvasculature in NFLD. We enrolled 15 glaucoma patients with DH history (32 glaucomatous NFLD locations, with or without DH history). NFLD-angle, superficial retinal vessel density (VD), and decreased superficial retinal microvasculature (deMv)-angle were assessed using optical coherence tomography angiography for at least three times over time. The mean follow-up period and OCT/OCTA scan interval were 21.3 ± 5.4 months (range, 12–28) and 6.8 ± 0.4 months (range, 2–18), respectively. Linear mixed-effects models showed that the presence of DH history was significantly associated with an additional NFLD-angle widening of 2.19 degree/year (P = 0.030), VD decrease of 1.88%/year (P = 0.015), and deMv-angle widening of 3.78 degree/year (P < 0.001). These changes were significantly correlated with each other (P < 0.001). Thus, the widening of NFLD was closely associated with deMv, and DH was associated with a subsequent decrease in superficial retinal microvasculature in NFLD.Yoko OkamotoTadamichi AkagiKenji SudaTakanori KamedaMasahiro MiyakeHanako Ohashi IkedaEri NakanoAkihito UjiAkitaka TsujikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoko Okamoto Tadamichi Akagi Kenji Suda Takanori Kameda Masahiro Miyake Hanako Ohashi Ikeda Eri Nakano Akihito Uji Akitaka Tsujikawa Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage
description	Abstract Glaucoma is a multifactorial optic neuropathy, possibly involving vascular dysfunction, leading to the death of retinal ganglion cells and their axons. Disc hemorrhage (DH) is known to be closely associated with the widening of retinal nerve fiber layer defect (NFLD); however, it has not been well elucidated how DH affects retinal microvasculature. We aimed to investigate the association between DH history and longitudinal changes in superficial retinal microvasculature in NFLD. We enrolled 15 glaucoma patients with DH history (32 glaucomatous NFLD locations, with or without DH history). NFLD-angle, superficial retinal vessel density (VD), and decreased superficial retinal microvasculature (deMv)-angle were assessed using optical coherence tomography angiography for at least three times over time. The mean follow-up period and OCT/OCTA scan interval were 21.3 ± 5.4 months (range, 12–28) and 6.8 ± 0.4 months (range, 2–18), respectively. Linear mixed-effects models showed that the presence of DH history was significantly associated with an additional NFLD-angle widening of 2.19 degree/year (P = 0.030), VD decrease of 1.88%/year (P = 0.015), and deMv-angle widening of 3.78 degree/year (P < 0.001). These changes were significantly correlated with each other (P < 0.001). Thus, the widening of NFLD was closely associated with deMv, and DH was associated with a subsequent decrease in superficial retinal microvasculature in NFLD.
format	article
author	Yoko Okamoto Tadamichi Akagi Kenji Suda Takanori Kameda Masahiro Miyake Hanako Ohashi Ikeda Eri Nakano Akihito Uji Akitaka Tsujikawa
author_facet	Yoko Okamoto Tadamichi Akagi Kenji Suda Takanori Kameda Masahiro Miyake Hanako Ohashi Ikeda Eri Nakano Akihito Uji Akitaka Tsujikawa
author_sort	Yoko Okamoto
title	Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage
title_short	Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage
title_full	Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage
title_fullStr	Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage
title_full_unstemmed	Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage
title_sort	longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/43657031cb2b433b81e75e6f0f80fe9a
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Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage

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