An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

The generation of a sustainable supply of erythroid progenitors is essential for the reliable production of anin vitroderived red blood cell clinical product. Here the authors immortalize early human erythroblasts to generate the first cell line capable of differentiation into functional adult retic...

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Autores principales:	Kongtana Trakarnsanga, Rebecca E. Griffiths, Marieangela C. Wilson, Allison Blair, Timothy J. Satchwell, Marjolein Meinders, Nicola Cogan, Sabine Kupzig, Ryo Kurita, Yukio Nakamura, Ashley M. Toye, David J. Anstee, Jan Frayne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43660dc1c27e4e12acb966c38920743b
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spelling	oai:doaj.org-article:43660dc1c27e4e12acb966c38920743b2021-12-02T17:06:06ZAn immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells10.1038/ncomms147502041-1723https://doaj.org/article/43660dc1c27e4e12acb966c38920743b2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14750https://doaj.org/toc/2041-1723The generation of a sustainable supply of erythroid progenitors is essential for the reliable production of anin vitroderived red blood cell clinical product. Here the authors immortalize early human erythroblasts to generate the first cell line capable of differentiation into functional adult reticulocytes.Kongtana TrakarnsangaRebecca E. GriffithsMarieangela C. WilsonAllison BlairTimothy J. SatchwellMarjolein MeindersNicola CoganSabine KupzigRyo KuritaYukio NakamuraAshley M. ToyeDavid J. AnsteeJan FrayneNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kongtana Trakarnsanga Rebecca E. Griffiths Marieangela C. Wilson Allison Blair Timothy J. Satchwell Marjolein Meinders Nicola Cogan Sabine Kupzig Ryo Kurita Yukio Nakamura Ashley M. Toye David J. Anstee Jan Frayne An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
description	The generation of a sustainable supply of erythroid progenitors is essential for the reliable production of anin vitroderived red blood cell clinical product. Here the authors immortalize early human erythroblasts to generate the first cell line capable of differentiation into functional adult reticulocytes.
format	article
author	Kongtana Trakarnsanga Rebecca E. Griffiths Marieangela C. Wilson Allison Blair Timothy J. Satchwell Marjolein Meinders Nicola Cogan Sabine Kupzig Ryo Kurita Yukio Nakamura Ashley M. Toye David J. Anstee Jan Frayne
author_facet	Kongtana Trakarnsanga Rebecca E. Griffiths Marieangela C. Wilson Allison Blair Timothy J. Satchwell Marjolein Meinders Nicola Cogan Sabine Kupzig Ryo Kurita Yukio Nakamura Ashley M. Toye David J. Anstee Jan Frayne
author_sort	Kongtana Trakarnsanga
title	An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
title_short	An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
title_full	An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
title_fullStr	An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
title_full_unstemmed	An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
title_sort	immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/43660dc1c27e4e12acb966c38920743b
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An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

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