Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells

Abstract The transcription factor Kruppel-like factor 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression and activity improves endothelial function and prevents atherosclerosis. However, the pharmacological and molecular regulato...

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Autores principales:	Yanni Xu, Peng Liu, Suowen Xu, Marina Koroleva, Shuya Zhang, Shuyi Si, Zheng Gen Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/436c6f3edf654a7d865b2f82daea638e
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spelling	oai:doaj.org-article:436c6f3edf654a7d865b2f82daea638e2021-12-02T11:52:55ZTannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells10.1038/s41598-017-06803-x2045-2322https://doaj.org/article/436c6f3edf654a7d865b2f82daea638e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06803-xhttps://doaj.org/toc/2045-2322Abstract The transcription factor Kruppel-like factor 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression and activity improves endothelial function and prevents atherosclerosis. However, the pharmacological and molecular regulators for KLF2 are scarce. Using high-throughput luciferase reporter assay to screen for KLF2 activators, we have identified tannic acid (TA), a polyphenolic compound, as a potent KLF2 activator that attenuates endothelial inflammation. Mechanistic studies suggested that TA induced KLF2 expression in part through the ERK5/MEF2 pathway. Functionally, TA markedly decreased monocyte adhesion to ECs by reducing expression of adhesion molecule VCAM1. Using lung ECs isolated from Klf2 +/+ and Klf2 +/− mice, we showed that the anti-inflammatory effect of TA is dependent on KLF2. Collectively, our results demonstrate that TA is a potent KLF2 activator and TA attenuated endothelial inflammation through upregulation of KLF2. Our findings provide a novel mechanism for the well-established beneficial cardiovascular effects of TA and suggest that KLF2 could be a novel therapeutic target for atherosclerotic vascular disease.Yanni XuPeng LiuSuowen XuMarina KorolevaShuya ZhangShuyi SiZheng Gen JinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanni Xu Peng Liu Suowen Xu Marina Koroleva Shuya Zhang Shuyi Si Zheng Gen Jin Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
description	Abstract The transcription factor Kruppel-like factor 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression and activity improves endothelial function and prevents atherosclerosis. However, the pharmacological and molecular regulators for KLF2 are scarce. Using high-throughput luciferase reporter assay to screen for KLF2 activators, we have identified tannic acid (TA), a polyphenolic compound, as a potent KLF2 activator that attenuates endothelial inflammation. Mechanistic studies suggested that TA induced KLF2 expression in part through the ERK5/MEF2 pathway. Functionally, TA markedly decreased monocyte adhesion to ECs by reducing expression of adhesion molecule VCAM1. Using lung ECs isolated from Klf2 +/+ and Klf2 +/− mice, we showed that the anti-inflammatory effect of TA is dependent on KLF2. Collectively, our results demonstrate that TA is a potent KLF2 activator and TA attenuated endothelial inflammation through upregulation of KLF2. Our findings provide a novel mechanism for the well-established beneficial cardiovascular effects of TA and suggest that KLF2 could be a novel therapeutic target for atherosclerotic vascular disease.
format	article
author	Yanni Xu Peng Liu Suowen Xu Marina Koroleva Shuya Zhang Shuyi Si Zheng Gen Jin
author_facet	Yanni Xu Peng Liu Suowen Xu Marina Koroleva Shuya Zhang Shuyi Si Zheng Gen Jin
author_sort	Yanni Xu
title	Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
title_short	Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
title_full	Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
title_fullStr	Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
title_full_unstemmed	Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
title_sort	tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing klf2 expression in endothelial cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/436c6f3edf654a7d865b2f82daea638e
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Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells

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