Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment

Aberrant cell cycle machinery and loss of the CDKN2A tumor suppressor locus make CDK4/6 a potential target in pancreatic ductal adenocarcinoma (PDAC). Here, the authors use ratiometrically designed nanoparticles to codeliver the CDK4/6 inhibitor palbociclib and the autophagy inhibitor hydroxychloroq...

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Autores principales:	Ying Ji, Xiangsheng Liu, Juan Li, Xiaodong Xie, Max Huang, Jinhong Jiang, Yu-Pei Liao, Timothy Donahue, Huan Meng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43701da3f8494ba7a8e1565db285cedd
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spelling	oai:doaj.org-article:43701da3f8494ba7a8e1565db285cedd2021-12-02T16:35:13ZUse of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment10.1038/s41467-020-17996-72041-1723https://doaj.org/article/43701da3f8494ba7a8e1565db285cedd2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17996-7https://doaj.org/toc/2041-1723Aberrant cell cycle machinery and loss of the CDKN2A tumor suppressor locus make CDK4/6 a potential target in pancreatic ductal adenocarcinoma (PDAC). Here, the authors use ratiometrically designed nanoparticles to codeliver the CDK4/6 inhibitor palbociclib and the autophagy inhibitor hydroxychloroquine, and show their synergistic therapeutic effects in mouse model of PDAC.Ying JiXiangsheng LiuJuan LiXiaodong XieMax HuangJinhong JiangYu-Pei LiaoTimothy DonahueHuan MengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Ji Xiangsheng Liu Juan Li Xiaodong Xie Max Huang Jinhong Jiang Yu-Pei Liao Timothy Donahue Huan Meng Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment
description	Aberrant cell cycle machinery and loss of the CDKN2A tumor suppressor locus make CDK4/6 a potential target in pancreatic ductal adenocarcinoma (PDAC). Here, the authors use ratiometrically designed nanoparticles to codeliver the CDK4/6 inhibitor palbociclib and the autophagy inhibitor hydroxychloroquine, and show their synergistic therapeutic effects in mouse model of PDAC.
format	article
author	Ying Ji Xiangsheng Liu Juan Li Xiaodong Xie Max Huang Jinhong Jiang Yu-Pei Liao Timothy Donahue Huan Meng
author_facet	Ying Ji Xiangsheng Liu Juan Li Xiaodong Xie Max Huang Jinhong Jiang Yu-Pei Liao Timothy Donahue Huan Meng
author_sort	Ying Ji
title	Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment
title_short	Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment
title_full	Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment
title_fullStr	Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment
title_full_unstemmed	Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment
title_sort	use of ratiometrically designed nanocarrier targeting cdk4/6 and autophagy pathways for effective pancreatic cancer treatment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/43701da3f8494ba7a8e1565db285cedd
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Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment

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