Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.

Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is...

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Autores principales:	Nadège Minois, Patrick Rockenfeller, Terry K Smith, Didac Carmona-Gutierrez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4371ef5fb0d64434873673ccd9dbf519
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id	oai:doaj.org-article:4371ef5fb0d64434873673ccd9dbf519
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spelling	oai:doaj.org-article:4371ef5fb0d64434873673ccd9dbf5192021-11-25T06:08:53ZSpermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.1932-620310.1371/journal.pone.0102435https://doaj.org/article/4371ef5fb0d64434873673ccd9dbf5192014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25010732/?tool=EBIhttps://doaj.org/toc/1932-6203Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.Nadège MinoisPatrick RockenfellerTerry K SmithDidac Carmona-GutierrezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102435 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadège Minois Patrick Rockenfeller Terry K Smith Didac Carmona-Gutierrez Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
description	Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.
format	article
author	Nadège Minois Patrick Rockenfeller Terry K Smith Didac Carmona-Gutierrez
author_facet	Nadège Minois Patrick Rockenfeller Terry K Smith Didac Carmona-Gutierrez
author_sort	Nadège Minois
title	Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
title_short	Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
title_full	Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
title_fullStr	Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
title_full_unstemmed	Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
title_sort	spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/4371ef5fb0d64434873673ccd9dbf519
work_keys_str_mv	AT nadegeminois spermidinefeedingdecreasesagerelatedlocomotoractivitylossandinduceschangesinlipidcomposition AT patrickrockenfeller spermidinefeedingdecreasesagerelatedlocomotoractivitylossandinduceschangesinlipidcomposition AT terryksmith spermidinefeedingdecreasesagerelatedlocomotoractivitylossandinduceschangesinlipidcomposition AT didaccarmonagutierrez spermidinefeedingdecreasesagerelatedlocomotoractivitylossandinduceschangesinlipidcomposition
_version_	1718414096383082496

Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.

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