Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches.

Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches.

The prion protein (PrP) is implicated in the Transmissible Spongiform Encephalopathies (TSEs), which comprise a group of fatal neurodegenerative diseases affecting humans and other mammals. Conversion of cellular PrP (PrP(C)) into the scrapie form (PrP(Sc)) is the hallmark of TSEs. Once formed, PrP(...

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Main Authors: Natalia C Ferreira, Icaro A Marques, Wesley A Conceição, Bruno Macedo, Clarice S Machado, Alessandra Mascarello, Louise Domeneghini Chiaradia-Delatorre, Rosendo Augusto Yunes, Ricardo José Nunes, Andrew G Hughson, Lynne D Raymond, Pedro G Pascutti, Byron Caughey, Yraima Cordeiro
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/43799d36574b4265a3fe221bb978ffb9
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https://doaj.org/article/43799d36574b4265a3fe221bb978ffb9

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