Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation

Abstract Breast cancer is the most common carcinoma in women, and natural products would be effective preventing some side effects of cancer treatment. In the present study, cytotoxic activities of different Iranian Chrysanthemum morifolium cultivars were evaluated in human breast cancer cell lines...

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Autores principales:	Mahboobeh Hodaei, Mehdi Rahimmalek, Mandana Behbahani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4381a967b60943028dc34278926244ff
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spelling	oai:doaj.org-article:4381a967b60943028dc34278926244ff2021-12-02T15:02:57ZAnticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation10.1038/s41598-021-91010-y2045-2322https://doaj.org/article/4381a967b60943028dc34278926244ff2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91010-yhttps://doaj.org/toc/2045-2322Abstract Breast cancer is the most common carcinoma in women, and natural products would be effective preventing some side effects of cancer treatment. In the present study, cytotoxic activities of different Iranian Chrysanthemum morifolium cultivars were evaluated in human breast cancer cell lines (MCF-7) and human lymphocytes. A systems pharmacology approach was employed between major compounds of these cultivars (chlorogenic acid, luteolin, quercetin, rutin, ferulic acid, and apigenin) and known breast cancer drugs (tucatinib, methotrexate, tamoxifen, and mitomycin) with 22 breast cancer-related targets to analyze the mechanism through which Chrysanthemum cultivars act on breast cancer. Target validation was performed by the molecular docking method. The results indicated that Chrysanthemum extracts inhibited the proliferation of MCF7 cells in a dose- and cultivar-dependent manner. In all studied cultivars, the most effective extract concentration with the lowest viability of MCF-7 cells, was as much as 312 µg ml−1. Also, higher concentrations of the extracts (> 1000 µg ml−1) reduced the lymphocyte cell viability, demonstrating that these doses were toxic. The gene ontology analysis revealed the therapeutic effects of Chrysanthemum’s active compounds on breast cancer by regulating the biological processes of their protein targets. Moreover, it has been documented that rutin, owing to its anticancer effects and several other health benefits, is a promising multi-targeted herbal ingredient. Finally, the present study compared different Iranian Chrysanthemum cultivars to provide new insights into useful pharmaceutical applications.Mahboobeh HodaeiMehdi RahimmalekMandana BehbahaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mahboobeh Hodaei Mehdi Rahimmalek Mandana Behbahani Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation
description	Abstract Breast cancer is the most common carcinoma in women, and natural products would be effective preventing some side effects of cancer treatment. In the present study, cytotoxic activities of different Iranian Chrysanthemum morifolium cultivars were evaluated in human breast cancer cell lines (MCF-7) and human lymphocytes. A systems pharmacology approach was employed between major compounds of these cultivars (chlorogenic acid, luteolin, quercetin, rutin, ferulic acid, and apigenin) and known breast cancer drugs (tucatinib, methotrexate, tamoxifen, and mitomycin) with 22 breast cancer-related targets to analyze the mechanism through which Chrysanthemum cultivars act on breast cancer. Target validation was performed by the molecular docking method. The results indicated that Chrysanthemum extracts inhibited the proliferation of MCF7 cells in a dose- and cultivar-dependent manner. In all studied cultivars, the most effective extract concentration with the lowest viability of MCF-7 cells, was as much as 312 µg ml−1. Also, higher concentrations of the extracts (> 1000 µg ml−1) reduced the lymphocyte cell viability, demonstrating that these doses were toxic. The gene ontology analysis revealed the therapeutic effects of Chrysanthemum’s active compounds on breast cancer by regulating the biological processes of their protein targets. Moreover, it has been documented that rutin, owing to its anticancer effects and several other health benefits, is a promising multi-targeted herbal ingredient. Finally, the present study compared different Iranian Chrysanthemum cultivars to provide new insights into useful pharmaceutical applications.
format	article
author	Mahboobeh Hodaei Mehdi Rahimmalek Mandana Behbahani
author_facet	Mahboobeh Hodaei Mehdi Rahimmalek Mandana Behbahani
author_sort	Mahboobeh Hodaei
title	Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation
title_short	Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation
title_full	Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation
title_fullStr	Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation
title_full_unstemmed	Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation
title_sort	anticancer drug discovery from iranian chrysanthemum cultivars through system pharmacology exploration and experimental validation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4381a967b60943028dc34278926244ff
work_keys_str_mv	AT mahboobehhodaei anticancerdrugdiscoveryfromiranianchrysanthemumcultivarsthroughsystempharmacologyexplorationandexperimentalvalidation AT mehdirahimmalek anticancerdrugdiscoveryfromiranianchrysanthemumcultivarsthroughsystempharmacologyexplorationandexperimentalvalidation AT mandanabehbahani anticancerdrugdiscoveryfromiranianchrysanthemumcultivarsthroughsystempharmacologyexplorationandexperimentalvalidation
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Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation

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