Translesion activity of PrimPol on DNA with cisplatin and DNA–protein cross-links

Abstract Human PrimPol belongs to the archaeo-eukaryotic primase superfamily of primases and is involved in de novo DNA synthesis downstream of blocking DNA lesions and non-B DNA structures. PrimPol possesses both DNA/RNA primase and DNA polymerase activities, and also bypasses a number of DNA lesio...

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Main Authors: Elizaveta O. Boldinova, Anna V. Yudkina, Evgeniy S. Shilkin, Diana I. Gagarinskaya, Andrey G. Baranovskiy, Tahir H. Tahirov, Dmitry O. Zharkov, Alena V. Makarova
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/4385708681084e81aa35235773846c76
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