Contribution of Membrane Lipids to Postsynaptic Protein Organization

The precise subsynaptic organization of proteins at the postsynaptic membrane controls synaptic transmission. In particular, postsynaptic receptor complexes are concentrated in distinct membrane nanodomains to optimize synaptic signaling. However, despite the clear functional relevance of subsynapti...

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Autores principales:	Manon Westra, Yolanda Gutierrez, Harold D. MacGillavry
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	synapse membrane lipid membrane organization synaptic plasiticity synaptic plasma membrane Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/43864fe71ca445a6bb124a4401ab155e
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spelling	oai:doaj.org-article:43864fe71ca445a6bb124a4401ab155e2021-11-30T12:30:26ZContribution of Membrane Lipids to Postsynaptic Protein Organization1663-356310.3389/fnsyn.2021.790773https://doaj.org/article/43864fe71ca445a6bb124a4401ab155e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnsyn.2021.790773/fullhttps://doaj.org/toc/1663-3563The precise subsynaptic organization of proteins at the postsynaptic membrane controls synaptic transmission. In particular, postsynaptic receptor complexes are concentrated in distinct membrane nanodomains to optimize synaptic signaling. However, despite the clear functional relevance of subsynaptic receptor organization to synaptic transmission and plasticity, the mechanisms that underlie the nanoscale organization of the postsynaptic membrane remain elusive. Over the last decades, the field has predominantly focused on the role of protein-protein interactions in receptor trafficking and positioning in the synaptic membrane. In contrast, the contribution of lipids, the principal constituents of the membrane, to receptor positioning at the synapse remains poorly understood. Nevertheless, there is compelling evidence that the synaptic membrane is enriched in specific lipid species and that deregulation of lipid homeostasis in neurons severely affects synaptic functioning. In this review we focus on how lipids are organized at the synaptic membrane, with special emphasis on how current models of membrane organization could contribute to protein distribution at the synapse and synaptic transmission. Finally, we will present an outlook on how novel technical developments could be applied to study the dynamic interplay between lipids and proteins at the postsynaptic membrane.Manon WestraYolanda GutierrezHarold D. MacGillavryFrontiers Media S.A.articlesynapsemembranelipidmembrane organizationsynaptic plasiticitysynaptic plasma membraneNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Synaptic Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	synapse membrane lipid membrane organization synaptic plasiticity synaptic plasma membrane Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	synapse membrane lipid membrane organization synaptic plasiticity synaptic plasma membrane Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Manon Westra Yolanda Gutierrez Harold D. MacGillavry Contribution of Membrane Lipids to Postsynaptic Protein Organization
description	The precise subsynaptic organization of proteins at the postsynaptic membrane controls synaptic transmission. In particular, postsynaptic receptor complexes are concentrated in distinct membrane nanodomains to optimize synaptic signaling. However, despite the clear functional relevance of subsynaptic receptor organization to synaptic transmission and plasticity, the mechanisms that underlie the nanoscale organization of the postsynaptic membrane remain elusive. Over the last decades, the field has predominantly focused on the role of protein-protein interactions in receptor trafficking and positioning in the synaptic membrane. In contrast, the contribution of lipids, the principal constituents of the membrane, to receptor positioning at the synapse remains poorly understood. Nevertheless, there is compelling evidence that the synaptic membrane is enriched in specific lipid species and that deregulation of lipid homeostasis in neurons severely affects synaptic functioning. In this review we focus on how lipids are organized at the synaptic membrane, with special emphasis on how current models of membrane organization could contribute to protein distribution at the synapse and synaptic transmission. Finally, we will present an outlook on how novel technical developments could be applied to study the dynamic interplay between lipids and proteins at the postsynaptic membrane.
format	article
author	Manon Westra Yolanda Gutierrez Harold D. MacGillavry
author_facet	Manon Westra Yolanda Gutierrez Harold D. MacGillavry
author_sort	Manon Westra
title	Contribution of Membrane Lipids to Postsynaptic Protein Organization
title_short	Contribution of Membrane Lipids to Postsynaptic Protein Organization
title_full	Contribution of Membrane Lipids to Postsynaptic Protein Organization
title_fullStr	Contribution of Membrane Lipids to Postsynaptic Protein Organization
title_full_unstemmed	Contribution of Membrane Lipids to Postsynaptic Protein Organization
title_sort	contribution of membrane lipids to postsynaptic protein organization
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/43864fe71ca445a6bb124a4401ab155e
work_keys_str_mv	AT manonwestra contributionofmembranelipidstopostsynapticproteinorganization AT yolandagutierrez contributionofmembranelipidstopostsynapticproteinorganization AT harolddmacgillavry contributionofmembranelipidstopostsynapticproteinorganization
_version_	1718406618043908096

Contribution of Membrane Lipids to Postsynaptic Protein Organization

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