Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.

<h4>Introduction</h4>Cardiovascular agents are pivotal in the therapy of heart failure. Apart from their action on ventricular contractility and systemic afterload, they affect pulmonary arteries and veins. Although these effects are crucial in heart failure with coexisting pulmonary hyp...

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Autores principales:	Annette D Rieg, Rolf Rossaint, Stefan Uhlig, Christian Martin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/438bac2ea0ae497fa2ac0e98348dbe99
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spelling	oai:doaj.org-article:438bac2ea0ae497fa2ac0e98348dbe992021-11-18T07:31:28ZCardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.1932-620310.1371/journal.pone.0029698https://doaj.org/article/438bac2ea0ae497fa2ac0e98348dbe992011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22216346/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Cardiovascular agents are pivotal in the therapy of heart failure. Apart from their action on ventricular contractility and systemic afterload, they affect pulmonary arteries and veins. Although these effects are crucial in heart failure with coexisting pulmonary hypertension or lung oedema, they are poorly defined, especially in pulmonary veins. Therefore, we investigated the pulmonary vascular effects of adrenoceptor agonists, vasopressin and angiotensin II in the model of precision-cut lung slices that allows simultaneous studies of pulmonary arteries and veins.<h4>Materials and methods</h4>Precision-cut lung slices were prepared from guinea pigs and imaged by videomicroscopy. Concentration-response curves of cardiovascular drugs were analysed in pulmonary arteries and veins.<h4>Results</h4>Pulmonary veins responded stronger than arteries to α(1)-agonists (contraction) and β(2)-agonists (relaxation). Notably, inhibition of β(2)-adrenoceptors unmasked the α(1)-mimetic effect of norepinephrine and epinephrine in pulmonary veins. Vasopressin and angiotensin II contracted pulmonary veins via V(1a) and AT(1) receptors, respectively, without affecting pulmonary arteries.<h4>Discussion</h4>Vasopressin and (nor)epinephrine in combination with β(2)-inhibition caused pulmonary venoconstriction. If applicable in humans, these treatments would enhance capillary hydrostatic pressures and lung oedema, suggesting their cautious use in left heart failure. Vice versa, the prevention of pulmonary venoconstriction by AT(1) receptor antagonists might contribute to their beneficial effects seen in left heart failure. Further, α(1)-mimetic agents might exacerbate pulmonary hypertension and right ventricular failure by contracting pulmonary arteries, whereas vasopressin might not.Annette D RiegRolf RossaintStefan UhligChristian MartinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e29698 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annette D Rieg Rolf Rossaint Stefan Uhlig Christian Martin Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
description	<h4>Introduction</h4>Cardiovascular agents are pivotal in the therapy of heart failure. Apart from their action on ventricular contractility and systemic afterload, they affect pulmonary arteries and veins. Although these effects are crucial in heart failure with coexisting pulmonary hypertension or lung oedema, they are poorly defined, especially in pulmonary veins. Therefore, we investigated the pulmonary vascular effects of adrenoceptor agonists, vasopressin and angiotensin II in the model of precision-cut lung slices that allows simultaneous studies of pulmonary arteries and veins.<h4>Materials and methods</h4>Precision-cut lung slices were prepared from guinea pigs and imaged by videomicroscopy. Concentration-response curves of cardiovascular drugs were analysed in pulmonary arteries and veins.<h4>Results</h4>Pulmonary veins responded stronger than arteries to α(1)-agonists (contraction) and β(2)-agonists (relaxation). Notably, inhibition of β(2)-adrenoceptors unmasked the α(1)-mimetic effect of norepinephrine and epinephrine in pulmonary veins. Vasopressin and angiotensin II contracted pulmonary veins via V(1a) and AT(1) receptors, respectively, without affecting pulmonary arteries.<h4>Discussion</h4>Vasopressin and (nor)epinephrine in combination with β(2)-inhibition caused pulmonary venoconstriction. If applicable in humans, these treatments would enhance capillary hydrostatic pressures and lung oedema, suggesting their cautious use in left heart failure. Vice versa, the prevention of pulmonary venoconstriction by AT(1) receptor antagonists might contribute to their beneficial effects seen in left heart failure. Further, α(1)-mimetic agents might exacerbate pulmonary hypertension and right ventricular failure by contracting pulmonary arteries, whereas vasopressin might not.
format	article
author	Annette D Rieg Rolf Rossaint Stefan Uhlig Christian Martin
author_facet	Annette D Rieg Rolf Rossaint Stefan Uhlig Christian Martin
author_sort	Annette D Rieg
title	Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
title_short	Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
title_full	Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
title_fullStr	Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
title_full_unstemmed	Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
title_sort	cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/438bac2ea0ae497fa2ac0e98348dbe99
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Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.

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