Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.

<h4>Aims</h4>To examine whether dynamic cerebral autoregulation is acutely impaired during maximal voluntary apnoea in trained divers.<h4>Methods</h4>Mean arterial pressure (MAP), cerebral blood flow-velocity (CBFV) and end-tidal partial pressures of O2 and CO2 (PETO2 and PET...

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Autores principales: Troy J Cross, Justin J Kavanagh, Toni Breskovic, Bruce D Johnson, Zeljko Dujic
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Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/438bbd5b9b8443b2a7e60f75eef72309
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spelling oai:doaj.org-article:438bbd5b9b8443b2a7e60f75eef723092021-11-18T08:34:15ZDynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.1932-620310.1371/journal.pone.0087598https://doaj.org/article/438bbd5b9b8443b2a7e60f75eef723092014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498340/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>To examine whether dynamic cerebral autoregulation is acutely impaired during maximal voluntary apnoea in trained divers.<h4>Methods</h4>Mean arterial pressure (MAP), cerebral blood flow-velocity (CBFV) and end-tidal partial pressures of O2 and CO2 (PETO2 and PETCO2) were measured in eleven trained, male apnoea divers (28 ± 2 yr; 182 ± 2 cm, 76 ± 7 kg) during maximal "dry" breath holding. Dynamic cerebral autoregulation was assessed by determining the strength of phase synchronisation between MAP and CBFV during maximal apnoea.<h4>Results</h4>The strength of phase synchronisation between MAP and CBFV increased from rest until the end of maximal voluntary apnoea (P<0.05), suggesting that dynamic cerebral autoregulation had weakened by the apnoea breakpoint. The magnitude of impairment in dynamic cerebral autoregulation was strongly, and positively related to the rise in PETCO2 observed during maximal breath holding (R (2) = 0.67, P<0.05). Interestingly, the impairment in dynamic cerebral autoregulation was not related to the fall in PETO2 induced by apnoea (R (2) = 0.01, P = 0.75).<h4>Conclusions</h4>This study is the first to report that dynamic cerebral autoregulation is acutely impaired in trained divers performing maximal voluntary apnoea. Furthermore, our data suggest that the impaired autoregulatory response is related to the change in PETCO2, but not PETO2, during maximal apnoea in trained divers.Troy J CrossJustin J KavanaghToni BreskovicBruce D JohnsonZeljko DujicPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e87598 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Troy J Cross
Justin J Kavanagh
Toni Breskovic
Bruce D Johnson
Zeljko Dujic
Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
description <h4>Aims</h4>To examine whether dynamic cerebral autoregulation is acutely impaired during maximal voluntary apnoea in trained divers.<h4>Methods</h4>Mean arterial pressure (MAP), cerebral blood flow-velocity (CBFV) and end-tidal partial pressures of O2 and CO2 (PETO2 and PETCO2) were measured in eleven trained, male apnoea divers (28 ± 2 yr; 182 ± 2 cm, 76 ± 7 kg) during maximal "dry" breath holding. Dynamic cerebral autoregulation was assessed by determining the strength of phase synchronisation between MAP and CBFV during maximal apnoea.<h4>Results</h4>The strength of phase synchronisation between MAP and CBFV increased from rest until the end of maximal voluntary apnoea (P<0.05), suggesting that dynamic cerebral autoregulation had weakened by the apnoea breakpoint. The magnitude of impairment in dynamic cerebral autoregulation was strongly, and positively related to the rise in PETCO2 observed during maximal breath holding (R (2) = 0.67, P<0.05). Interestingly, the impairment in dynamic cerebral autoregulation was not related to the fall in PETO2 induced by apnoea (R (2) = 0.01, P = 0.75).<h4>Conclusions</h4>This study is the first to report that dynamic cerebral autoregulation is acutely impaired in trained divers performing maximal voluntary apnoea. Furthermore, our data suggest that the impaired autoregulatory response is related to the change in PETCO2, but not PETO2, during maximal apnoea in trained divers.
format article
author Troy J Cross
Justin J Kavanagh
Toni Breskovic
Bruce D Johnson
Zeljko Dujic
author_facet Troy J Cross
Justin J Kavanagh
Toni Breskovic
Bruce D Johnson
Zeljko Dujic
author_sort Troy J Cross
title Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
title_short Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
title_full Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
title_fullStr Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
title_full_unstemmed Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
title_sort dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/438bbd5b9b8443b2a7e60f75eef72309
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