New Tools for Syphilis Research

ABSTRACT Syphilis research has been severely limited by the necessity to propagate Treponema pallidum in vivo in rabbits. After decades of erroneous or irreproducible reports of cultivation of T. pallidum, the recent very convincing report of its successful long-term in vitro propagation opens numer...

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Autor principal:	Sheila A. Lukehart
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	infectious disease sexually transmitted diseases syphilis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/438c20afe6ab43c2b02673d87c97badd
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spelling	oai:doaj.org-article:438c20afe6ab43c2b02673d87c97badd2021-11-15T16:00:16ZNew Tools for Syphilis Research10.1128/mBio.01417-182150-7511https://doaj.org/article/438c20afe6ab43c2b02673d87c97badd2018-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01417-18https://doaj.org/toc/2150-7511ABSTRACT Syphilis research has been severely limited by the necessity to propagate Treponema pallidum in vivo in rabbits. After decades of erroneous or irreproducible reports of cultivation of T. pallidum, the recent very convincing report of its successful long-term in vitro propagation opens numerous opportunities for development of genetic tools for studying pathogenesis and protein function, antigenic variation, and surface exposure of antigens. The possibility of more rapid isolation of new strains will expand our knowledge of this organism beyond the century-old Nichols strain.Sheila A. LukehartAmerican Society for Microbiologyarticleinfectious diseasesexually transmitted diseasessyphilisMicrobiologyQR1-502ENmBio, Vol 9, Iss 4 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	infectious disease sexually transmitted diseases syphilis Microbiology QR1-502
spellingShingle	infectious disease sexually transmitted diseases syphilis Microbiology QR1-502 Sheila A. Lukehart New Tools for Syphilis Research
description	ABSTRACT Syphilis research has been severely limited by the necessity to propagate Treponema pallidum in vivo in rabbits. After decades of erroneous or irreproducible reports of cultivation of T. pallidum, the recent very convincing report of its successful long-term in vitro propagation opens numerous opportunities for development of genetic tools for studying pathogenesis and protein function, antigenic variation, and surface exposure of antigens. The possibility of more rapid isolation of new strains will expand our knowledge of this organism beyond the century-old Nichols strain.
format	article
author	Sheila A. Lukehart
author_facet	Sheila A. Lukehart
author_sort	Sheila A. Lukehart
title	New Tools for Syphilis Research
title_short	New Tools for Syphilis Research
title_full	New Tools for Syphilis Research
title_fullStr	New Tools for Syphilis Research
title_full_unstemmed	New Tools for Syphilis Research
title_sort	new tools for syphilis research
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/438c20afe6ab43c2b02673d87c97badd
work_keys_str_mv	AT sheilaalukehart newtoolsforsyphilisresearch
_version_	1718426961772019712

New Tools for Syphilis Research

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