Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period

Abstract The functional role of thyroid hormone (TH) in the cortex and hippocampus of mouse during neuronal development was investigated in this study. TH insufficiency showed a decrease in the expression of parvalbumin (PV) in the cortex and hippocampus of pups at postnatal day (PD) 14, while treat...

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Autores principales:	Katsuya Uchida, Kentaro Hasuoka, Toshimitsu Fuse, Kenichi Kobayashi, Takahiro Moriya, Mao Suzuki, Norihiro Katayama, Keiichi Itoi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/438d0b2042f04881bf963b816ed5d7bf
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spelling	oai:doaj.org-article:438d0b2042f04881bf963b816ed5d7bf2021-12-02T11:45:03ZThyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period10.1038/s41598-021-86237-82045-2322https://doaj.org/article/438d0b2042f04881bf963b816ed5d7bf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86237-8https://doaj.org/toc/2045-2322Abstract The functional role of thyroid hormone (TH) in the cortex and hippocampus of mouse during neuronal development was investigated in this study. TH insufficiency showed a decrease in the expression of parvalbumin (PV) in the cortex and hippocampus of pups at postnatal day (PD) 14, while treatment with thyroxine from PD 0 to PD 14 ameliorated the PV loss. On the other hand, treatment with antithyroid agents in adulthood did not result in a decrease in the expression of PV in these areas. These results indicate the existence of a critical period of TH action during the early postnatal period. A decrease in MeCP2-positive neuronal nuclei was also observed in the cortical layers II–IV of the cerebral cortex. The brains were then stained with CUX1, a marker for cortical layers II–IV. In comparison with normal mice, CUX1 signals were decreased in the somatosensory cortex of the hypothyroid mice, and the total thickness of cortical layers II–IV of the mice was lower than that of normal mice. These results suggest that TH insufficiency during the perinatal period strongly and broadly affects neuronal development.Katsuya UchidaKentaro HasuokaToshimitsu FuseKenichi KobayashiTakahiro MoriyaMao SuzukiNorihiro KatayamaKeiichi ItoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katsuya Uchida Kentaro Hasuoka Toshimitsu Fuse Kenichi Kobayashi Takahiro Moriya Mao Suzuki Norihiro Katayama Keiichi Itoi Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period
description	Abstract The functional role of thyroid hormone (TH) in the cortex and hippocampus of mouse during neuronal development was investigated in this study. TH insufficiency showed a decrease in the expression of parvalbumin (PV) in the cortex and hippocampus of pups at postnatal day (PD) 14, while treatment with thyroxine from PD 0 to PD 14 ameliorated the PV loss. On the other hand, treatment with antithyroid agents in adulthood did not result in a decrease in the expression of PV in these areas. These results indicate the existence of a critical period of TH action during the early postnatal period. A decrease in MeCP2-positive neuronal nuclei was also observed in the cortical layers II–IV of the cerebral cortex. The brains were then stained with CUX1, a marker for cortical layers II–IV. In comparison with normal mice, CUX1 signals were decreased in the somatosensory cortex of the hypothyroid mice, and the total thickness of cortical layers II–IV of the mice was lower than that of normal mice. These results suggest that TH insufficiency during the perinatal period strongly and broadly affects neuronal development.
format	article
author	Katsuya Uchida Kentaro Hasuoka Toshimitsu Fuse Kenichi Kobayashi Takahiro Moriya Mao Suzuki Norihiro Katayama Keiichi Itoi
author_facet	Katsuya Uchida Kentaro Hasuoka Toshimitsu Fuse Kenichi Kobayashi Takahiro Moriya Mao Suzuki Norihiro Katayama Keiichi Itoi
author_sort	Katsuya Uchida
title	Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period
title_short	Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period
title_full	Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period
title_fullStr	Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period
title_full_unstemmed	Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period
title_sort	thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/438d0b2042f04881bf963b816ed5d7bf
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Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period

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