Prostate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study

Abstract Prostate cancer is the third most common cancer in Malaysia with the lifetime risk of 1 in 117 men. Here, we initiated a longitudinal Malaysia Prostate Cancer (M‐CaP) Study to investigate the clinical and tumour characteristics, treatment patterns as well as disease outcomes of multi‐ethnic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jasmine Lim, Rohan Malek, Sathiyananthan JR, Charng C. Toh, Murali Sundram, Susan Y. Y. Woo, Noor A. M. Yusoff, Guan C. Teh, Benjamin J. T. Chui, Ing S. Ngu, S. Thevarajah, Wei J. Koh, Say B. Lee, Say C. Khoo, Boon W. Teoh, Rohana Zainal, Teck M. Tham, Shamsuddin Omar, Noor A. Nasuha, Hideyuki Akaza, Teng A. Ong, M‐CaP Study
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Asia advanced prostate cancer cancer care disparities cancer registry The A‐CaP Study Group Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/439470e9529e40dd8b90ec005d140c0a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:439470e9529e40dd8b90ec005d140c0a
record_format	dspace
spelling	oai:doaj.org-article:439470e9529e40dd8b90ec005d140c0a2021-11-22T09:08:47ZProstate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study2045-763410.1002/cam4.4319https://doaj.org/article/439470e9529e40dd8b90ec005d140c0a2021-11-01T00:00:00Zhttps://doi.org/10.1002/cam4.4319https://doaj.org/toc/2045-7634Abstract Prostate cancer is the third most common cancer in Malaysia with the lifetime risk of 1 in 117 men. Here, we initiated a longitudinal Malaysia Prostate Cancer (M‐CaP) Study to investigate the clinical and tumour characteristics, treatment patterns as well as disease outcomes of multi‐ethnic Asian men at real‐world setting. The M‐CaP database consisted of 1839 new patients with prostate cancer diagnosed between 2016 and 2018 from nine public urology referral centres across Malaysia. Basic demographic and clinical parameters, tumour characteristics, primary treatment, follow‐up and vital status data were retrieved prospectively from the hospital‐based patients’ case notes or electronic medical records. Primary endpoints were overall survival (OS) and biochemical progression‐free survival (bPFS). The median age at diagnosis of M‐CaP patients was 70 years (interquartile range, IQR 65–75). Majority of patients were Chinese (831, 45.2%), followed by Malays (704, 38.3%), Indians (124, 6.7%) and other races (181, 9.8%). The median follow‐up for all patients was 23.5 months (IQR 15.9–33.6). Although 58.1% presented with late‐stage cancer, we observed ethnic and geographic disparities in late‐stage prostate cancer diagnosis. Curative radiotherapy and primary androgen deprivation therapy were the most common treatment for stage III and stage IV diseases, respectively. The median OS and bPFS of stage IV patients were 40.1 months and 19.2 months (95% CI 17.6–20.8), respectively. Late stage at presentation remains a challenge in multi‐ethnic Asian men. Early detection is imperative to improve treatment outcome and survival of patients with prostate cancer.Jasmine LimRohan MalekSathiyananthan JRCharng C. TohMurali SundramSusan Y. Y. WooNoor A. M. YusoffGuan C. TehBenjamin J. T. ChuiIng S. NguS. ThevarajahWei J. KohSay B. LeeSay C. KhooBoon W. TeohRohana ZainalTeck M. ThamShamsuddin OmarNoor A. NasuhaHideyuki AkazaTeng A. OngM‐CaP StudyWileyarticleAsiaadvanced prostate cancercancer care disparitiescancer registryThe A‐CaP Study GroupNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 22, Pp 8020-8028 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asia advanced prostate cancer cancer care disparities cancer registry The A‐CaP Study Group Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Asia advanced prostate cancer cancer care disparities cancer registry The A‐CaP Study Group Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jasmine Lim Rohan Malek Sathiyananthan JR Charng C. Toh Murali Sundram Susan Y. Y. Woo Noor A. M. Yusoff Guan C. Teh Benjamin J. T. Chui Ing S. Ngu S. Thevarajah Wei J. Koh Say B. Lee Say C. Khoo Boon W. Teoh Rohana Zainal Teck M. Tham Shamsuddin Omar Noor A. Nasuha Hideyuki Akaza Teng A. Ong M‐CaP Study Prostate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study
description	Abstract Prostate cancer is the third most common cancer in Malaysia with the lifetime risk of 1 in 117 men. Here, we initiated a longitudinal Malaysia Prostate Cancer (M‐CaP) Study to investigate the clinical and tumour characteristics, treatment patterns as well as disease outcomes of multi‐ethnic Asian men at real‐world setting. The M‐CaP database consisted of 1839 new patients with prostate cancer diagnosed between 2016 and 2018 from nine public urology referral centres across Malaysia. Basic demographic and clinical parameters, tumour characteristics, primary treatment, follow‐up and vital status data were retrieved prospectively from the hospital‐based patients’ case notes or electronic medical records. Primary endpoints were overall survival (OS) and biochemical progression‐free survival (bPFS). The median age at diagnosis of M‐CaP patients was 70 years (interquartile range, IQR 65–75). Majority of patients were Chinese (831, 45.2%), followed by Malays (704, 38.3%), Indians (124, 6.7%) and other races (181, 9.8%). The median follow‐up for all patients was 23.5 months (IQR 15.9–33.6). Although 58.1% presented with late‐stage cancer, we observed ethnic and geographic disparities in late‐stage prostate cancer diagnosis. Curative radiotherapy and primary androgen deprivation therapy were the most common treatment for stage III and stage IV diseases, respectively. The median OS and bPFS of stage IV patients were 40.1 months and 19.2 months (95% CI 17.6–20.8), respectively. Late stage at presentation remains a challenge in multi‐ethnic Asian men. Early detection is imperative to improve treatment outcome and survival of patients with prostate cancer.
format	article
author	Jasmine Lim Rohan Malek Sathiyananthan JR Charng C. Toh Murali Sundram Susan Y. Y. Woo Noor A. M. Yusoff Guan C. Teh Benjamin J. T. Chui Ing S. Ngu S. Thevarajah Wei J. Koh Say B. Lee Say C. Khoo Boon W. Teoh Rohana Zainal Teck M. Tham Shamsuddin Omar Noor A. Nasuha Hideyuki Akaza Teng A. Ong M‐CaP Study
author_facet	Jasmine Lim Rohan Malek Sathiyananthan JR Charng C. Toh Murali Sundram Susan Y. Y. Woo Noor A. M. Yusoff Guan C. Teh Benjamin J. T. Chui Ing S. Ngu S. Thevarajah Wei J. Koh Say B. Lee Say C. Khoo Boon W. Teoh Rohana Zainal Teck M. Tham Shamsuddin Omar Noor A. Nasuha Hideyuki Akaza Teng A. Ong M‐CaP Study
author_sort	Jasmine Lim
title	Prostate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study
title_short	Prostate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study
title_full	Prostate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study
title_fullStr	Prostate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study
title_full_unstemmed	Prostate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study
title_sort	prostate cancer in multi‐ethnic asian men: real‐world experience in the malaysia prostate cancer (m‐cap) study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/439470e9529e40dd8b90ec005d140c0a
work_keys_str_mv	AT jasminelim prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT rohanmalek prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT sathiyananthanjr prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT charngctoh prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT muralisundram prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT susanyywoo prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT nooramyusoff prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT guancteh prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT benjaminjtchui prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT ingsngu prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT sthevarajah prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT weijkoh prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT sayblee prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT sayckhoo prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT boonwteoh prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT rohanazainal prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT teckmtham prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT shamsuddinomar prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT nooranasuha prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT hideyukiakaza prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT tengaong prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy AT mcapstudy prostatecancerinmultiethnicasianmenrealworldexperienceinthemalaysiaprostatecancermcapstudy
_version_	1718417789973168128

Prostate cancer in multi‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study

Ejemplares similares