FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS

Abstract. Some functional properties of IFNα-induced dendritic cells (DCs) from the patients with pulmonary tuberculosis (PT) were under study. It was revealed that production of IFNγ and IFNα by DCs of the patients was decreased, but TNFα production was preserved at normal level. NO production by D...

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Autores principales:	L. V. Sakhno, O. Yu. Leplina, Zh. M. Raspay, M. A. Tikhonova, E. V. Kurganova, I. P. Gileva, S. D. Nikonov, O. A. Zhdanov, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	dendritic cells cytokines th1/th2 pulmonary tuberculosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/439743640c8e490cadd03ac88cadc002
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spelling	oai:doaj.org-article:439743640c8e490cadd03ac88cadc0022021-11-18T08:03:38ZFUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2008-2-3-151-158https://doaj.org/article/439743640c8e490cadd03ac88cadc0022014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/113https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Some functional properties of IFNα-induced dendritic cells (DCs) from the patients with pulmonary tuberculosis (PT) were under study. It was revealed that production of IFNγ and IFNα by DCs of the patients was decreased, but TNFα production was preserved at normal level. NO production by DCs from the patients was also reduced. In addition, it has been shown, that DCs of PT patients were characterized by low allostimulatory activity in mixed lymphocyte reaction (MLR), and this defect was more marked in the patients with PPD-anergy. As compared to healthy donors, DCs from the patients with PT (in particular, with PPD-anergy) exhibited a decreased capacity for induction of intracellular expression and production of IFNγ by T-cells. However, DCs from the patients with PPD-anergy were able to stimulate intracellular expression of IL-4 in CD3+T-cell subset. Hence, the results suggest that functional activity of DCs in the patients with PT is altered, and some of these changes are distinctly associated with decreased antigen-specific response. (Med. Immunol., 2008, vol. 10, N 2-3, pp 151-158).L. V. SakhnoO. Yu. LeplinaZh. M. RaspayM. A. TikhonovaE. V. KurganovaI. P. GilevaS. D. NikonovO. A. ZhdanovA. A. OstaninE. R. ChernykhSPb RAACIarticledendritic cellscytokinesth1/th2pulmonary tuberculosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 151-158 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	dendritic cells cytokines th1/th2 pulmonary tuberculosis Immunologic diseases. Allergy RC581-607
spellingShingle	dendritic cells cytokines th1/th2 pulmonary tuberculosis Immunologic diseases. Allergy RC581-607 L. V. Sakhno O. Yu. Leplina Zh. M. Raspay M. A. Tikhonova E. V. Kurganova I. P. Gileva S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS
description	Abstract. Some functional properties of IFNα-induced dendritic cells (DCs) from the patients with pulmonary tuberculosis (PT) were under study. It was revealed that production of IFNγ and IFNα by DCs of the patients was decreased, but TNFα production was preserved at normal level. NO production by DCs from the patients was also reduced. In addition, it has been shown, that DCs of PT patients were characterized by low allostimulatory activity in mixed lymphocyte reaction (MLR), and this defect was more marked in the patients with PPD-anergy. As compared to healthy donors, DCs from the patients with PT (in particular, with PPD-anergy) exhibited a decreased capacity for induction of intracellular expression and production of IFNγ by T-cells. However, DCs from the patients with PPD-anergy were able to stimulate intracellular expression of IL-4 in CD3+T-cell subset. Hence, the results suggest that functional activity of DCs in the patients with PT is altered, and some of these changes are distinctly associated with decreased antigen-specific response. (Med. Immunol., 2008, vol. 10, N 2-3, pp 151-158).
format	article
author	L. V. Sakhno O. Yu. Leplina Zh. M. Raspay M. A. Tikhonova E. V. Kurganova I. P. Gileva S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh
author_facet	L. V. Sakhno O. Yu. Leplina Zh. M. Raspay M. A. Tikhonova E. V. Kurganova I. P. Gileva S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh
author_sort	L. V. Sakhno
title	FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS
title_short	FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS
title_full	FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS
title_fullStr	FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS
title_full_unstemmed	FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS
title_sort	functional properties of ifnα-induced dendritic cells in the patients with pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/439743640c8e490cadd03ac88cadc002
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FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS

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