Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent protein kinase reverts MFS aortopathy in mice.
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Nature Portfolio
2021
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oai:doaj.org-article:439b8e5d5511412680725f97df82754a2021-12-02T17:02:04ZAortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO10.1038/s41467-021-22933-32041-1723https://doaj.org/article/439b8e5d5511412680725f97df82754a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22933-3https://doaj.org/toc/2041-1723Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent protein kinase reverts MFS aortopathy in mice.Andrea de la Fuente-AlonsoMarta ToralAlvaro AlfayateMaría Jesús Ruiz-RodríguezElena Bonzón-KulichenkoGisela Teixido-TuraSara Martínez-MartínezMaría José Méndez-OlivaresDolores López-MaderueloIleana González-ValdésEusebio Garcia-IzquierdoSusana MingoCarlos E. MartínLaura Muiño-MosqueraJulie De BackerJ. Francisco NistalAlberto FortezaArturo EvangelistaJesús VázquezMiguel R. CampaneroJuan Miguel RedondoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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DOAJ |
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EN |
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Science Q Andrea de la Fuente-Alonso Marta Toral Alvaro Alfayate María Jesús Ruiz-Rodríguez Elena Bonzón-Kulichenko Gisela Teixido-Tura Sara Martínez-Martínez María José Méndez-Olivares Dolores López-Maderuelo Ileana González-Valdés Eusebio Garcia-Izquierdo Susana Mingo Carlos E. Martín Laura Muiño-Mosquera Julie De Backer J. Francisco Nistal Alberto Forteza Arturo Evangelista Jesús Vázquez Miguel R. Campanero Juan Miguel Redondo Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO |
| description |
Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent protein kinase reverts MFS aortopathy in mice. |
| format |
article |
| author |
Andrea de la Fuente-Alonso Marta Toral Alvaro Alfayate María Jesús Ruiz-Rodríguez Elena Bonzón-Kulichenko Gisela Teixido-Tura Sara Martínez-Martínez María José Méndez-Olivares Dolores López-Maderuelo Ileana González-Valdés Eusebio Garcia-Izquierdo Susana Mingo Carlos E. Martín Laura Muiño-Mosquera Julie De Backer J. Francisco Nistal Alberto Forteza Arturo Evangelista Jesús Vázquez Miguel R. Campanero Juan Miguel Redondo |
| author_facet |
Andrea de la Fuente-Alonso Marta Toral Alvaro Alfayate María Jesús Ruiz-Rodríguez Elena Bonzón-Kulichenko Gisela Teixido-Tura Sara Martínez-Martínez María José Méndez-Olivares Dolores López-Maderuelo Ileana González-Valdés Eusebio Garcia-Izquierdo Susana Mingo Carlos E. Martín Laura Muiño-Mosquera Julie De Backer J. Francisco Nistal Alberto Forteza Arturo Evangelista Jesús Vázquez Miguel R. Campanero Juan Miguel Redondo |
| author_sort |
Andrea de la Fuente-Alonso |
| title |
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO |
| title_short |
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO |
| title_full |
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO |
| title_fullStr |
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO |
| title_full_unstemmed |
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO |
| title_sort |
aortic disease in marfan syndrome is caused by overactivation of sgc-prkg signaling by no |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/439b8e5d5511412680725f97df82754a |
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