Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses

Jing-Hui Zheng, Gui-Lan Ning, Wen-Hua Xu, Xin-Cheng Wu, Xiao-Cong Ma Department of Cardiology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China Background: In recent years, there has been substantial research evaluating the relationship between arachidon...

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Autores principales:	Zheng J, Ning G, Xu W, Wen X, Ma X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	ischemic stroke ALOX5AP genetic polymorphism haplotype Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/439e2a95c7df4fdfaee2827dd9fec046
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spelling	oai:doaj.org-article:439e2a95c7df4fdfaee2827dd9fec0462021-12-02T04:03:48ZLack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses1178-2021https://doaj.org/article/439e2a95c7df4fdfaee2827dd9fec0462019-01-01T00:00:00Zhttps://www.dovepress.com/lack-of-association-between-alox5ap-genetic-polymorphisms-and-risk-of--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jing-Hui Zheng, Gui-Lan Ning, Wen-Hua Xu, Xin-Cheng Wu, Xiao-Cong Ma Department of Cardiology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China Background: In recent years, there has been substantial research evaluating the relationship between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) polymorphisms and ischemic stroke (IS). The objective of this study was to systematically review and analyze the existing evidence.Methods: A comprehensive search of major electronic databases for studies published between 1990 and 2018 was carried out. Data were synthesized as OR and 95% CI using fixed-effects and random-effects models.Results: A total of 30 studies were available for analysis. The aggregate sample size across all studies was 32,782 (16,294 cases and 16,488 controls). We found no association of the ALOX5AP rs10507391 (OR=1.03 for A allele vs T allele; 95% CI: 0.93–1.14; P=0.557), rs4769874 (OR=1.13 for A allele vs G allele; 95% CI: 1.00–1.28; P=0.050), rs9551963 (OR=1.03 for A allele vs C allele; 95% CI: 0.96–1.11; P=0.372), rs17222814 (OR=1.09 for A allele vs G allele; 95% CI: 0.96–1.24; P=0.195), rs17222919 (OR=0.89 for G allele vs T allele; 95% CI: 0.75–1.06; P=0.175), and rs4073259 (OR=1.20 for A allele vs G allele; 95% CI: 1.00–1.45; P=0.056) polymorphisms with IS risk. Haplotype analysis also did not yield significant findings for the HapA (rs17222814G–rs10507391T–rs4769874G–rs9551963A; OR=1.20; 95% CI: 0.91–1.56; P=0.192) and HapB (rs17216473A–rs10507391A–rs9315050A–rs17222842G; OR=1.11; 95% CI: 0.90–1.38; P=0.339) haplotypes.Conclusion: Current evidence does not support an association of rs10507391, rs4769874, rs9551963, rs17222814, rs17222919, rs4073259, and HapA and HapB with IS risk. Keywords: ischemic stroke, ALOX5AP, genetic polymorphism, haplotype  Zheng JNing GXu WWen XMa XDove Medical Pressarticleischemic strokeALOX5APgenetic polymorphismhaplotypeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 357-367 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ischemic stroke ALOX5AP genetic polymorphism haplotype Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ischemic stroke ALOX5AP genetic polymorphism haplotype Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zheng J Ning G Xu W Wen X Ma X Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses
description	Jing-Hui Zheng, Gui-Lan Ning, Wen-Hua Xu, Xin-Cheng Wu, Xiao-Cong Ma Department of Cardiology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China Background: In recent years, there has been substantial research evaluating the relationship between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) polymorphisms and ischemic stroke (IS). The objective of this study was to systematically review and analyze the existing evidence.Methods: A comprehensive search of major electronic databases for studies published between 1990 and 2018 was carried out. Data were synthesized as OR and 95% CI using fixed-effects and random-effects models.Results: A total of 30 studies were available for analysis. The aggregate sample size across all studies was 32,782 (16,294 cases and 16,488 controls). We found no association of the ALOX5AP rs10507391 (OR=1.03 for A allele vs T allele; 95% CI: 0.93–1.14; P=0.557), rs4769874 (OR=1.13 for A allele vs G allele; 95% CI: 1.00–1.28; P=0.050), rs9551963 (OR=1.03 for A allele vs C allele; 95% CI: 0.96–1.11; P=0.372), rs17222814 (OR=1.09 for A allele vs G allele; 95% CI: 0.96–1.24; P=0.195), rs17222919 (OR=0.89 for G allele vs T allele; 95% CI: 0.75–1.06; P=0.175), and rs4073259 (OR=1.20 for A allele vs G allele; 95% CI: 1.00–1.45; P=0.056) polymorphisms with IS risk. Haplotype analysis also did not yield significant findings for the HapA (rs17222814G–rs10507391T–rs4769874G–rs9551963A; OR=1.20; 95% CI: 0.91–1.56; P=0.192) and HapB (rs17216473A–rs10507391A–rs9315050A–rs17222842G; OR=1.11; 95% CI: 0.90–1.38; P=0.339) haplotypes.Conclusion: Current evidence does not support an association of rs10507391, rs4769874, rs9551963, rs17222814, rs17222919, rs4073259, and HapA and HapB with IS risk. Keywords: ischemic stroke, ALOX5AP, genetic polymorphism, haplotype
format	article
author	Zheng J Ning G Xu W Wen X Ma X
author_facet	Zheng J Ning G Xu W Wen X Ma X
author_sort	Zheng J
title	Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses
title_short	Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses
title_full	Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses
title_fullStr	Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses
title_full_unstemmed	Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses
title_sort	lack of association between alox5ap genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/439e2a95c7df4fdfaee2827dd9fec046
work_keys_str_mv	AT zhengj lackofassociationbetweenalox5apgeneticpolymorphismsandriskofischemicstrokeevidencefrommetaanalyses AT ningg lackofassociationbetweenalox5apgeneticpolymorphismsandriskofischemicstrokeevidencefrommetaanalyses AT xuw lackofassociationbetweenalox5apgeneticpolymorphismsandriskofischemicstrokeevidencefrommetaanalyses AT wenx lackofassociationbetweenalox5apgeneticpolymorphismsandriskofischemicstrokeevidencefrommetaanalyses AT max lackofassociationbetweenalox5apgeneticpolymorphismsandriskofischemicstrokeevidencefrommetaanalyses
_version_	1718401426626969600

Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses

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