The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes

Abstract The COVID-19 pandemic has affected more than 100 million cases and caused immense burdens on governments and healthcare systems worldwide. Since its emergence in December 2019, research has been focused on treating the infected, identifying those at risk and preventing spread. There is curr...

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Autores principales:	Marwa Ali Almadhi, Abdulkarim Abdulrahman, Abdulla Alawadhi, Ali A. Rabaan, Stephen Atkin, Manaf AlQahtani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/439f1272d58c4e9eb2562905cbe49056
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spelling	oai:doaj.org-article:439f1272d58c4e9eb2562905cbe490562021-12-02T11:37:25ZThe effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes10.1038/s41598-021-84810-92045-2322https://doaj.org/article/439f1272d58c4e9eb2562905cbe490562021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84810-9https://doaj.org/toc/2045-2322Abstract The COVID-19 pandemic has affected more than 100 million cases and caused immense burdens on governments and healthcare systems worldwide. Since its emergence in December 2019, research has been focused on treating the infected, identifying those at risk and preventing spread. There is currently no known biological biomarker that predicts the risk of infection. Several studies emerged suggesting an association between ABO blood group and the risk of COVID-19 infection. In this study, we used retrospective observational data in Bahrain to investigate the association between ABO blood group and risk of infection, as well as susceptibility to severe ICU-requiring infection. We found a higher risk associated with blood group B, and a lower risk with blood group AB. No association was observed between blood group and the risk of a severe ICU-requiring infection. We extended the analysis to study the association by antibodies; anti-a (blood groups B and O) and anti-b (blood groups A and O). No association between antibodies and both risk of infection or susceptibility to severe infection was found. The current study, along with the variation in blood group association results, indicates that blood group may not be an ideal biomarker to predict risk of COVID-19 infection.Marwa Ali AlmadhiAbdulkarim AbdulrahmanAbdulla AlawadhiAli A. RabaanStephen AtkinManaf AlQahtaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marwa Ali Almadhi Abdulkarim Abdulrahman Abdulla Alawadhi Ali A. Rabaan Stephen Atkin Manaf AlQahtani The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes
description	Abstract The COVID-19 pandemic has affected more than 100 million cases and caused immense burdens on governments and healthcare systems worldwide. Since its emergence in December 2019, research has been focused on treating the infected, identifying those at risk and preventing spread. There is currently no known biological biomarker that predicts the risk of infection. Several studies emerged suggesting an association between ABO blood group and the risk of COVID-19 infection. In this study, we used retrospective observational data in Bahrain to investigate the association between ABO blood group and risk of infection, as well as susceptibility to severe ICU-requiring infection. We found a higher risk associated with blood group B, and a lower risk with blood group AB. No association was observed between blood group and the risk of a severe ICU-requiring infection. We extended the analysis to study the association by antibodies; anti-a (blood groups B and O) and anti-b (blood groups A and O). No association between antibodies and both risk of infection or susceptibility to severe infection was found. The current study, along with the variation in blood group association results, indicates that blood group may not be an ideal biomarker to predict risk of COVID-19 infection.
format	article
author	Marwa Ali Almadhi Abdulkarim Abdulrahman Abdulla Alawadhi Ali A. Rabaan Stephen Atkin Manaf AlQahtani
author_facet	Marwa Ali Almadhi Abdulkarim Abdulrahman Abdulla Alawadhi Ali A. Rabaan Stephen Atkin Manaf AlQahtani
author_sort	Marwa Ali Almadhi
title	The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes
title_short	The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes
title_full	The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes
title_fullStr	The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes
title_full_unstemmed	The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes
title_sort	effect of abo blood group and antibody class on the risk of covid-19 infection and severity of clinical outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/439f1272d58c4e9eb2562905cbe49056
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The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes

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