The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis

Background Multiple sclerosis (MS) is an autoimmune disease leading to physical, emotional and cognitive disability. High body mass index (BMI) may impact cognitive function and brain volume in MS. Yet, there is paucity of evidence addressing the impact of BMI on cognitive function and brain volume...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aliza Bitton Ben-Zacharia, Malvin N. Janal, Abraham A. Brody, Jerry Wolinsky, Fred Lublin, Gary Cutter
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/439f3bd6be1a4d728a522c39357626fc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:439f3bd6be1a4d728a522c39357626fc
record_format	dspace
spelling	oai:doaj.org-article:439f3bd6be1a4d728a522c39357626fc2021-11-06T22:03:21ZThe Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis1179-573510.1177/11795735211042173https://doaj.org/article/439f3bd6be1a4d728a522c39357626fc2021-11-01T00:00:00Zhttps://doi.org/10.1177/11795735211042173https://doaj.org/toc/1179-5735Background Multiple sclerosis (MS) is an autoimmune disease leading to physical, emotional and cognitive disability. High body mass index (BMI) may impact cognitive function and brain volume in MS. Yet, there is paucity of evidence addressing the impact of BMI on cognitive function and brain volume in MS. Objectives The purpose of this study was to examine the effects of BMI on normal appearing brain volume and cognitive function in patients with relapsing–remitting MS. Methods A secondary data analysis of the NIH CombiRx study was conducted. Multivariate regression and mixed model analyses were executed to analyze the effect of BMI on brain volume and cognitive function. Results The mean baseline age of the 768 participants was 38.2(SD = 9.4) years. 73% were female and 88.8% were Caucasian. The mean BMI was 28.8 kg/m 2 (SD = 6.7). The multivariate regression and mixed model analyses failed to show a clinical effect of BMI on brain volume and cognitive function. Conclusion BMI did not show an effect on cognitive function and brain volume among MS patients. Although there is increased interest in the effects of modifiable factors on the course of MS, the effects of BMI on brain volume and cognitive function are debatable and warrant further research. ClinicalTrials.gov NCT00211887Aliza Bitton Ben-ZachariaMalvin N. JanalAbraham A. BrodyJerry WolinskyFred LublinGary CutterSAGE PublishingarticleNeurology. Diseases of the nervous systemRC346-429ENJournal of Central Nervous System Disease, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Aliza Bitton Ben-Zacharia Malvin N. Janal Abraham A. Brody Jerry Wolinsky Fred Lublin Gary Cutter The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis
description	Background Multiple sclerosis (MS) is an autoimmune disease leading to physical, emotional and cognitive disability. High body mass index (BMI) may impact cognitive function and brain volume in MS. Yet, there is paucity of evidence addressing the impact of BMI on cognitive function and brain volume in MS. Objectives The purpose of this study was to examine the effects of BMI on normal appearing brain volume and cognitive function in patients with relapsing–remitting MS. Methods A secondary data analysis of the NIH CombiRx study was conducted. Multivariate regression and mixed model analyses were executed to analyze the effect of BMI on brain volume and cognitive function. Results The mean baseline age of the 768 participants was 38.2(SD = 9.4) years. 73% were female and 88.8% were Caucasian. The mean BMI was 28.8 kg/m 2 (SD = 6.7). The multivariate regression and mixed model analyses failed to show a clinical effect of BMI on brain volume and cognitive function. Conclusion BMI did not show an effect on cognitive function and brain volume among MS patients. Although there is increased interest in the effects of modifiable factors on the course of MS, the effects of BMI on brain volume and cognitive function are debatable and warrant further research. ClinicalTrials.gov NCT00211887
format	article
author	Aliza Bitton Ben-Zacharia Malvin N. Janal Abraham A. Brody Jerry Wolinsky Fred Lublin Gary Cutter
author_facet	Aliza Bitton Ben-Zacharia Malvin N. Janal Abraham A. Brody Jerry Wolinsky Fred Lublin Gary Cutter
author_sort	Aliza Bitton Ben-Zacharia
title	The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis
title_short	The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis
title_full	The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis
title_fullStr	The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis
title_full_unstemmed	The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis
title_sort	effect of body mass index on brain volume and cognitive function in relapsing–remitting multiple sclerosis: a combirx secondary analysis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/439f3bd6be1a4d728a522c39357626fc
work_keys_str_mv	AT alizabittonbenzacharia theeffectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT malvinnjanal theeffectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT abrahamabrody theeffectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT jerrywolinsky theeffectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT fredlublin theeffectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT garycutter theeffectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT alizabittonbenzacharia effectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT malvinnjanal effectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT abrahamabrody effectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT jerrywolinsky effectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT fredlublin effectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis AT garycutter effectofbodymassindexonbrainvolumeandcognitivefunctioninrelapsingremittingmultiplesclerosisacombirxsecondaryanalysis
_version_	1718443663676145664

The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis

Ejemplares similares