Socioeconomic position links circulatory microbiota differences with biological age

Abstract Imbalanced nutrition is associated with accelerated ageing, possibly mediated by microbiota. An analysis of the circulatory microbiota obtained from the leukocytes of participants in the MRC Twenty-07 general population cohort was performed. We now report that in this cohort, the most biolo...

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Autores principales:	Hannah Craven, Dagmara McGuinness, Sarah Buchanan, Norman Galbraith, David H. McGuinness, Brian Jones, Emilie Combet, Denise Mafra, Peter Bergman, Anne Ellaway, Peter Stenvinkel, Umer Z. Ijaz, Paul G. Shiels
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43a0c2f267634c6980c3f708b9bbbf26
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spelling	oai:doaj.org-article:43a0c2f267634c6980c3f708b9bbbf262021-12-02T17:40:49ZSocioeconomic position links circulatory microbiota differences with biological age10.1038/s41598-021-92042-02045-2322https://doaj.org/article/43a0c2f267634c6980c3f708b9bbbf262021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92042-0https://doaj.org/toc/2045-2322Abstract Imbalanced nutrition is associated with accelerated ageing, possibly mediated by microbiota. An analysis of the circulatory microbiota obtained from the leukocytes of participants in the MRC Twenty-07 general population cohort was performed. We now report that in this cohort, the most biologically aged exhibit a significantly higher abundance of circulatory pathogenic bacteria, including Neisseria, Rothia and Porphyromonas, while those less biologically aged possess more circulatory salutogenic (defined as being supportive of human health and wellbeing) bacteria, including Lactobacillus, Lachnospiraceae UCG-004 and Kocuria. The presence of these salutogenic bactreria is consistent with a capacity to metabolise and produce Nrf2 agonists. We also demonstrate that associated one carbon metabolism, notably betaine levels, did not vary with chronological age, but displayed a difference with socioeconomic position (SEP). Those at lower SEP possessed significantly lower betaine levels indicative of a poorer diet and poorer health span and consistent with reduced global DNA methylation levels in this group. Our data suggest a clear route to improving age related health and resilience based on dietary modulation of the microbiota.Hannah CravenDagmara McGuinnessSarah BuchananNorman GalbraithDavid H. McGuinnessBrian JonesEmilie CombetDenise MafraPeter BergmanAnne EllawayPeter StenvinkelUmer Z. IjazPaul G. ShielsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hannah Craven Dagmara McGuinness Sarah Buchanan Norman Galbraith David H. McGuinness Brian Jones Emilie Combet Denise Mafra Peter Bergman Anne Ellaway Peter Stenvinkel Umer Z. Ijaz Paul G. Shiels Socioeconomic position links circulatory microbiota differences with biological age
description	Abstract Imbalanced nutrition is associated with accelerated ageing, possibly mediated by microbiota. An analysis of the circulatory microbiota obtained from the leukocytes of participants in the MRC Twenty-07 general population cohort was performed. We now report that in this cohort, the most biologically aged exhibit a significantly higher abundance of circulatory pathogenic bacteria, including Neisseria, Rothia and Porphyromonas, while those less biologically aged possess more circulatory salutogenic (defined as being supportive of human health and wellbeing) bacteria, including Lactobacillus, Lachnospiraceae UCG-004 and Kocuria. The presence of these salutogenic bactreria is consistent with a capacity to metabolise and produce Nrf2 agonists. We also demonstrate that associated one carbon metabolism, notably betaine levels, did not vary with chronological age, but displayed a difference with socioeconomic position (SEP). Those at lower SEP possessed significantly lower betaine levels indicative of a poorer diet and poorer health span and consistent with reduced global DNA methylation levels in this group. Our data suggest a clear route to improving age related health and resilience based on dietary modulation of the microbiota.
format	article
author	Hannah Craven Dagmara McGuinness Sarah Buchanan Norman Galbraith David H. McGuinness Brian Jones Emilie Combet Denise Mafra Peter Bergman Anne Ellaway Peter Stenvinkel Umer Z. Ijaz Paul G. Shiels
author_facet	Hannah Craven Dagmara McGuinness Sarah Buchanan Norman Galbraith David H. McGuinness Brian Jones Emilie Combet Denise Mafra Peter Bergman Anne Ellaway Peter Stenvinkel Umer Z. Ijaz Paul G. Shiels
author_sort	Hannah Craven
title	Socioeconomic position links circulatory microbiota differences with biological age
title_short	Socioeconomic position links circulatory microbiota differences with biological age
title_full	Socioeconomic position links circulatory microbiota differences with biological age
title_fullStr	Socioeconomic position links circulatory microbiota differences with biological age
title_full_unstemmed	Socioeconomic position links circulatory microbiota differences with biological age
title_sort	socioeconomic position links circulatory microbiota differences with biological age
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43a0c2f267634c6980c3f708b9bbbf26
work_keys_str_mv	AT hannahcraven socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT dagmaramcguinness socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT sarahbuchanan socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT normangalbraith socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT davidhmcguinness socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT brianjones socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT emiliecombet socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT denisemafra socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT peterbergman socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT anneellaway socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT peterstenvinkel socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT umerzijaz socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage AT paulgshiels socioeconomicpositionlinkscirculatorymicrobiotadifferenceswithbiologicalage
_version_	1718379699825016832

Socioeconomic position links circulatory microbiota differences with biological age

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