Heart failure and preserved left ventricular function: long term clinical outcome.

<h4>Background</h4>Patients with heart failure (HF) have a poor prognosis. The proportion of patients with HF and preserved left ventricular function (LVF) is increasing. Long term prognosis of HF with preserved LVF may not be so benign.<h4>Objectives</h4>To evaluate the long...

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Autores principales:	Israel Gotsman, Donna Zwas, Chaim Lotan, Andre Keren
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43a45f87aad043818c62dba0794b7c0d
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spelling	oai:doaj.org-article:43a45f87aad043818c62dba0794b7c0d2021-11-18T07:11:51ZHeart failure and preserved left ventricular function: long term clinical outcome.1932-620310.1371/journal.pone.0041022https://doaj.org/article/43a45f87aad043818c62dba0794b7c0d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22829907/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Patients with heart failure (HF) have a poor prognosis. The proportion of patients with HF and preserved left ventricular function (LVF) is increasing. Long term prognosis of HF with preserved LVF may not be so benign.<h4>Objectives</h4>To evaluate the long term clinical outcome of patients with HF and preserved LVF and predictors of outcome.<h4>Methods</h4>We prospectively evaluated 309 patients hospitalized with a definite clinical diagnosis of HF. Patients were followed for a mean of 6.5 years for clinical outcome.<h4>Results</h4>More than a third (36%) of the patients had preserved systolic LVF based on echocardiography. The long term survival rate in this group was poor and not significantly different from patients with reduced LVF (28% vs 23% respectively, P=0.2). The adjusted survival rate by Cox regression analysis was also not significantly different (hazard ratio 1.16, 95% confidence interval 0.87-1.55, P=0.31). The event free survival from death or heart failure re-hospitalization was also low in both groups and not significantly different between patients with preserved vs. reduced LVF (12% vs. 10% respectively, P=0.2). Predictors of mortality in patients with preserved LVF were age, functional capacity and serum urea levels.<h4>Conclusions</h4>The long term clinical outcome of patients with heart failure and preserved LVF is poor and not significantly different from patients with reduced LVF.Israel GotsmanDonna ZwasChaim LotanAndre KerenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41022 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Israel Gotsman Donna Zwas Chaim Lotan Andre Keren Heart failure and preserved left ventricular function: long term clinical outcome.
description	<h4>Background</h4>Patients with heart failure (HF) have a poor prognosis. The proportion of patients with HF and preserved left ventricular function (LVF) is increasing. Long term prognosis of HF with preserved LVF may not be so benign.<h4>Objectives</h4>To evaluate the long term clinical outcome of patients with HF and preserved LVF and predictors of outcome.<h4>Methods</h4>We prospectively evaluated 309 patients hospitalized with a definite clinical diagnosis of HF. Patients were followed for a mean of 6.5 years for clinical outcome.<h4>Results</h4>More than a third (36%) of the patients had preserved systolic LVF based on echocardiography. The long term survival rate in this group was poor and not significantly different from patients with reduced LVF (28% vs 23% respectively, P=0.2). The adjusted survival rate by Cox regression analysis was also not significantly different (hazard ratio 1.16, 95% confidence interval 0.87-1.55, P=0.31). The event free survival from death or heart failure re-hospitalization was also low in both groups and not significantly different between patients with preserved vs. reduced LVF (12% vs. 10% respectively, P=0.2). Predictors of mortality in patients with preserved LVF were age, functional capacity and serum urea levels.<h4>Conclusions</h4>The long term clinical outcome of patients with heart failure and preserved LVF is poor and not significantly different from patients with reduced LVF.
format	article
author	Israel Gotsman Donna Zwas Chaim Lotan Andre Keren
author_facet	Israel Gotsman Donna Zwas Chaim Lotan Andre Keren
author_sort	Israel Gotsman
title	Heart failure and preserved left ventricular function: long term clinical outcome.
title_short	Heart failure and preserved left ventricular function: long term clinical outcome.
title_full	Heart failure and preserved left ventricular function: long term clinical outcome.
title_fullStr	Heart failure and preserved left ventricular function: long term clinical outcome.
title_full_unstemmed	Heart failure and preserved left ventricular function: long term clinical outcome.
title_sort	heart failure and preserved left ventricular function: long term clinical outcome.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/43a45f87aad043818c62dba0794b7c0d
work_keys_str_mv	AT israelgotsman heartfailureandpreservedleftventricularfunctionlongtermclinicaloutcome AT donnazwas heartfailureandpreservedleftventricularfunctionlongtermclinicaloutcome AT chaimlotan heartfailureandpreservedleftventricularfunctionlongtermclinicaloutcome AT andrekeren heartfailureandpreservedleftventricularfunctionlongtermclinicaloutcome
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Heart failure and preserved left ventricular function: long term clinical outcome.

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