Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon

In eukaryotic cells, the ubiquitylation system regulates several cellular processes central to protein homoeostasis. Here the authors demonstrate the existence of an eukaryotic-like ubiquitylation cascade requiring E1, E2 and E3-like enzymes in the archaeon C. subterraneum, shedding light on the evo...

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Autores principales:	Rory Hennell James, Eva F. Caceres, Alex Escasinas, Haya Alhasan, Julie A. Howard, Michael J. Deery, Thijs J. G. Ettema, Nicholas P. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43a479c725a04e099f110faf35387e01
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spelling	oai:doaj.org-article:43a479c725a04e099f110faf35387e012021-12-02T15:38:50ZFunctional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon10.1038/s41467-017-01162-72041-1723https://doaj.org/article/43a479c725a04e099f110faf35387e012017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01162-7https://doaj.org/toc/2041-1723In eukaryotic cells, the ubiquitylation system regulates several cellular processes central to protein homoeostasis. Here the authors demonstrate the existence of an eukaryotic-like ubiquitylation cascade requiring E1, E2 and E3-like enzymes in the archaeon C. subterraneum, shedding light on the evolution of the ubiquitin-proteasome system.Rory Hennell JamesEva F. CaceresAlex EscasinasHaya AlhasanJulie A. HowardMichael J. DeeryThijs J. G. EttemaNicholas P. RobinsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rory Hennell James Eva F. Caceres Alex Escasinas Haya Alhasan Julie A. Howard Michael J. Deery Thijs J. G. Ettema Nicholas P. Robinson Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
description	In eukaryotic cells, the ubiquitylation system regulates several cellular processes central to protein homoeostasis. Here the authors demonstrate the existence of an eukaryotic-like ubiquitylation cascade requiring E1, E2 and E3-like enzymes in the archaeon C. subterraneum, shedding light on the evolution of the ubiquitin-proteasome system.
format	article
author	Rory Hennell James Eva F. Caceres Alex Escasinas Haya Alhasan Julie A. Howard Michael J. Deery Thijs J. G. Ettema Nicholas P. Robinson
author_facet	Rory Hennell James Eva F. Caceres Alex Escasinas Haya Alhasan Julie A. Howard Michael J. Deery Thijs J. G. Ettema Nicholas P. Robinson
author_sort	Rory Hennell James
title	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_short	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_full	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_fullStr	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_full_unstemmed	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_sort	functional reconstruction of a eukaryotic-like e1/e2/(ring) e3 ubiquitylation cascade from an uncultured archaeon
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/43a479c725a04e099f110faf35387e01
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Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon

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