Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon

In eukaryotic cells, the ubiquitylation system regulates several cellular processes central to protein homoeostasis. Here the authors demonstrate the existence of an eukaryotic-like ubiquitylation cascade requiring E1, E2 and E3-like enzymes in the archaeon C. subterraneum, shedding light on the evo...

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Autores principales: Rory Hennell James, Eva F. Caceres, Alex Escasinas, Haya Alhasan, Julie A. Howard, Michael J. Deery, Thijs J. G. Ettema, Nicholas P. Robinson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/43a479c725a04e099f110faf35387e01
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