<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry

The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.

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Autores principales:	Melina Vallbracht, Henriette Lötzsch, Barbara G. Klupp, Walter Fuchs, Benjamin Vollmer, Kay Grünewald, Marija Backovic, Felix A. Rey, Thomas C. Mettenleiter
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/43a561b2c81d4a709bcf0876adf1eaf4
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spelling	oai:doaj.org-article:43a561b2c81d4a709bcf0876adf1eaf42021-11-03T21:15:03Z <i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry 2150-751110.1128/mBio.00557-21https://doaj.org/article/43a561b2c81d4a709bcf0876adf1eaf42021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00557-21https://doaj.org/toc/2150-7511 The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.Melina VallbrachtHenriette LötzschBarbara G. KluppWalter FuchsBenjamin VollmerKay GrünewaldMarija BackovicFelix A. ReyThomas C. MettenleiterAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Melina Vallbracht Henriette Lötzsch Barbara G. Klupp Walter Fuchs Benjamin Vollmer Kay Grünewald Marija Backovic Felix A. Rey Thomas C. Mettenleiter <i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
description	The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.
format	article
author	Melina Vallbracht Henriette Lötzsch Barbara G. Klupp Walter Fuchs Benjamin Vollmer Kay Grünewald Marija Backovic Felix A. Rey Thomas C. Mettenleiter
author_facet	Melina Vallbracht Henriette Lötzsch Barbara G. Klupp Walter Fuchs Benjamin Vollmer Kay Grünewald Marija Backovic Felix A. Rey Thomas C. Mettenleiter
author_sort	Melina Vallbracht
title	<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
title_short	<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
title_full	<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
title_fullStr	<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
title_full_unstemmed	<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
title_sort	<i>in vitro</i> viral evolution identifies a critical residue in the alphaherpesvirus fusion glycoprotein b ectodomain that controls gh/gl-independent entry
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/43a561b2c81d4a709bcf0876adf1eaf4
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<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry

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